{"id":"W4327675561","doi":"10.1093/aje/kwad057","title":"Optimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine","year":2023,"lang":"en","type":"article","venue":"American Journal of Epidemiology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Nursing Research; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Eye Institute; National Institute on Aging; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Government of Alberta; Agency for Healthcare Research and Quality; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Health Resources and Services Administration; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; National Institute of Dental and Craniofacial Research; Centers for Disease Control and Prevention","keywords":"Efavirenz; Regimen; Medicine; Internal medicine; Confidence interval; Cohort; Reverse-transcriptase inhibitor; Pediatrics; Viral load; Human immunodeficiency virus (HIV); Immunology; Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03091476,0.001191662,0.002818977,0.001546626,0.0004409012,0.002474888,0.001092808,0.00119957,0.0008787786],"category_scores_gemma":[0.06931926,0.0005064742,0.002654872,0.001355262,0.001152179,0.001631996,0.001169069,0.001531024,0.0001580097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001992669,"about_ca_system_score_gemma":0.003867067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00455662,"about_ca_topic_score_gemma":0.004008471,"domain_scores_codex":[0.9743298,0.01890765,0.001355042,0.002157786,0.002670127,0.0005796469],"domain_scores_gemma":[0.9597168,0.02973317,0.006758525,0.002330002,0.001159204,0.0003023884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.002332294,0.0006151727,0.1272377,0.001409152,0.007122636,0.0002035544,0.0004125805,0.5073724,0.002786225,0.02253117,0.004662024,0.3233151],"study_design_scores_gemma":[0.001561273,0.004893496,0.0914879,0.001694509,0.005783021,0.000687505,0.000372474,0.6859611,0.009430453,0.1818254,0.01591979,0.0003830649],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3447706,0.03771255,0.5950779,0.009658956,0.0004926479,0.001018282,0.00210645,0.0009130219,0.008249583],"genre_scores_gemma":[0.9054409,0.003756568,0.08769297,0.001722233,0.0001783974,0.0002445422,0.0005401093,0.00004248364,0.0003819212],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03091476,"threshold_uncertainty_score":0.1634949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1727406204627607,"score_gpt":0.4871029224319855,"score_spread":0.3143623019692248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}