{"id":"W4327675837","doi":"10.1093/molbev/msad061","title":"Evolutionary Trajectories are Contingent on Mitonuclear Interactions","year":2023,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; PROTEO","funders":"Fonds de Recherche du Québec - Santé; European Commission","keywords":"Biology; Epistasis; Genome; Genetics; Nuclear gene; Evolutionary biology; Mitochondrial DNA; Genome evolution; Gene; Haplotype; Allele; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258116,0.0001554081,0.0001221977,0.0001208501,0.0002127581,0.00001118825,0.00009089994,0.0001871344,0.00001405485],"category_scores_gemma":[0.0001219534,0.0001567329,0.00008232424,0.000180485,0.0001723436,0.000003701501,0.00009283704,0.0001195772,0.00009204646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003126198,"about_ca_system_score_gemma":0.00003182695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001691851,"about_ca_topic_score_gemma":0.00004075782,"domain_scores_codex":[0.9989988,0.0001122233,0.0001653582,0.0003877141,0.00006798469,0.0002679833],"domain_scores_gemma":[0.9995345,0.00001458307,0.00007160057,0.0002315248,0.00007048609,0.0000773246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002274209,0.0001153189,0.04992778,0.0000213741,0.0001461744,0.00001141237,0.00005763753,0.001483687,0.9072046,0.02470001,0.01507588,0.001028697],"study_design_scores_gemma":[0.001623783,0.001274352,0.8537289,0.00006240482,0.00007981514,0.0001063142,0.0007201605,0.009189652,0.01472435,0.01000842,0.10758,0.0009018925],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984365,0.0008070731,0.01204174,0.0009089489,0.0005168954,0.0001589455,0.00004795094,0.00009113903,0.001062233],"genre_scores_gemma":[0.9976246,0.0001739576,0.0003263837,0.0003251342,0.0001601118,0.00002790339,0.0003749625,0.00001911743,0.0009677929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8924803,"threshold_uncertainty_score":0.6391383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007090742403751363,"score_gpt":0.2725160565999682,"score_spread":0.2654253141962168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}