{"id":"W4327675837","doi":"10.1093/molbev/msad061","title":"Evolutionary Trajectories are Contingent on Mitonuclear Interactions","year":2023,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; PROTEO","funders":"Fonds de Recherche du Québec - Santé; European Commission","keywords":"Biology; Epistasis; Genome; Genetics; Nuclear gene; Evolutionary biology; Mitochondrial DNA; Genome evolution; Gene; Haplotype; Allele; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000491915,0.0002371437,0.0003445788,0.0004913608,0.000422752,0.000730948,0.0002734527,0.0003022939,0.0008366223],"category_scores_gemma":[0.001686989,0.0001699364,0.0001994916,0.0004577226,0.0004942891,0.0004830787,0.0008847341,0.0004709956,0.0001399403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003975224,"about_ca_system_score_gemma":0.0002214901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004606461,"about_ca_topic_score_gemma":0.0009232356,"domain_scores_codex":[0.9996157,0.0001184886,0.00002843735,0.0001250865,0.00006956141,0.0000426159],"domain_scores_gemma":[0.9991348,0.0003638371,0.0002262364,0.0001139949,0.00008338486,0.00007783071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005792594,0.00009708603,0.09723538,0.0001699927,0.0001615679,0.0004316061,0.0006873622,0.01744273,0.8468206,0.006943937,0.000145329,0.02928518],"study_design_scores_gemma":[0.00006766916,0.0008177356,0.7833227,0.00005653059,0.0002455572,0.001658383,0.001306295,0.09346327,0.09467857,0.01655187,0.007645125,0.0001862712],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973004,0.00007741425,0.001932006,0.00002068947,0.000001630788,0.000004559948,0.00005068726,0.00001477308,0.0005977074],"genre_scores_gemma":[0.9975954,0.0001079136,0.001913992,0.00001303527,0.000002013261,0.00001376519,0.000147456,0.00001411465,0.0001923673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008366223,"threshold_uncertainty_score":0.002884209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007090742403751363,"score_gpt":0.2725160565999682,"score_spread":0.2654253141962168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}