{"id":"W4327677487","doi":"10.1093/nar/gkad172","title":"Excessive transcription-replication conflicts are a vulnerability of <i>BRCA1</i>-mutant cancers","year":2023,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Department of Medical Biophysics, University of Toronto; Canadian Institutes of Health Research; Terry Fox Foundation; University of Birmingham; Generalitat de Catalunya; Cancer Research UK; University of Toronto; Canadian Cancer Society; Centres de Recerca de Catalunya; Government of Ontario; Cancer Research Society; European Regional Development Fund; Princess Margaret Cancer Foundation; Samuel Waxman Cancer Research Foundation","keywords":"Biology; CRISPR; Transcription (linguistics); RNA polymerase II; Genetics; Cell biology; Mutant; Transcription factor; Cancer research; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654274,0.0003184355,0.0003077756,0.0002499085,0.0002401437,0.0004827476,0.0002297118,0.0003484635,0.001532244],"category_scores_gemma":[0.0002653876,0.0002113164,0.0002611647,0.0001199152,0.0002721167,0.0002267634,0.0004505543,0.0005074636,0.0003578487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270548,"about_ca_system_score_gemma":0.0001795665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003443916,"about_ca_topic_score_gemma":0.000483108,"domain_scores_codex":[0.9997497,0.00003005746,0.00001651876,0.00006856051,0.00009521571,0.00003981753],"domain_scores_gemma":[0.9997813,0.00004008898,0.0001041313,0.00002536822,0.0000133958,0.0000357279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003906969,0.000006657812,0.0006845885,0.00002576396,0.000008652143,0.0001827807,0.00001282774,0.0001455281,0.9966792,0.0001452309,0.00005289865,0.002016798],"study_design_scores_gemma":[0.000004265873,0.0001160259,0.008218883,0.000006968752,0.00001790015,0.002892502,0.00004122567,0.001180485,0.9832678,0.0002332221,0.004010519,0.00001021204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800171,0.00226976,0.01398201,0.000179379,0.00002858536,0.00003053547,0.0003899058,0.0005362432,0.002566419],"genre_scores_gemma":[0.9951606,0.0004880516,0.00279877,0.00005953401,0.000005431166,0.00001442827,0.0002318686,0.00004422446,0.001197067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532244,"threshold_uncertainty_score":0.00512588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05049404743878888,"score_gpt":0.3971324716392961,"score_spread":0.3466384242005072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}