{"id":"W4327678290","doi":"10.1161/circresaha.122.321858","title":"Enhanced Ca <sup>2+</sup> -Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation","year":2023,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; Novo Nordisk; ZonMw; Deutsche Forschungsgemeinschaft; European Commission; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Gating; Atrial fibrillation; Cardiology; Internal medicine; Chemistry; Membrane potential; Biophysics; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658004,0.000191235,0.0002289376,0.0001592825,0.0001017421,0.0002173829,0.0001271076,0.0002963453,0.001599862],"category_scores_gemma":[0.0002551835,0.00008749682,0.0001806451,0.0001127829,0.0002137273,0.0001619485,0.0001488771,0.0002485676,0.0003364104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000138473,"about_ca_system_score_gemma":0.00008205685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002455827,"about_ca_topic_score_gemma":0.0001849848,"domain_scores_codex":[0.9999337,0.00001095653,0.00001002342,0.0000226194,0.00001173452,0.00001099086],"domain_scores_gemma":[0.9998813,0.00003198367,0.00004128126,0.00001207214,0.00001359587,0.00001979656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002539097,0.00004501843,0.01287663,0.0001316265,0.00001682842,0.001004115,0.0000794488,0.0001842757,0.9778208,0.00006510584,0.00008750518,0.005149584],"study_design_scores_gemma":[0.0001901622,0.002999697,0.3554108,0.00003513614,0.000140225,0.01634409,0.0002212339,0.004262676,0.6169633,0.0004859302,0.002924945,0.00002169569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974164,0.001070822,0.0009371399,0.0000442407,0.000008277861,0.00001001667,0.0001226934,0.00002403997,0.0003663148],"genre_scores_gemma":[0.9989226,0.000309195,0.0004067197,0.00002798774,0.000007487033,0.00001037123,0.0001541504,0.00000518949,0.0001562499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001599862,"threshold_uncertainty_score":0.00535202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05552581587766472,"score_gpt":0.3691422534295795,"score_spread":0.3136164375519148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}