{"id":"W4327683716","doi":"10.1371/journal.pone.0283164","title":"Efficacy of ANTHRASIL (Anthrax Immune Globulin Intravenous (Human)) in rabbit and nonhuman primate models of inhalational anthrax: Data supporting approval under animal rule","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Biomedical Advanced Research and Development Authority; U.S. Department of Health and Human Services","keywords":"Bacillus anthracis; Anthrax vaccines; Medicine; Immune system; Immunology; Pharmacodynamics; Pharmacology; Antibody; Biology; Immunization; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01053198,0.001015864,0.001667306,0.0008331554,0.0006782587,0.001471718,0.001119372,0.002099061,0.006331504],"category_scores_gemma":[0.004032949,0.0005529016,0.001007374,0.0007387646,0.001454699,0.0009353012,0.0003534128,0.002035055,0.002829662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007307488,"about_ca_system_score_gemma":0.001610666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001020918,"about_ca_topic_score_gemma":0.001788755,"domain_scores_codex":[0.9948854,0.002537145,0.0006530957,0.0004839243,0.001054239,0.0003862054],"domain_scores_gemma":[0.9939903,0.001083803,0.001623053,0.001400729,0.001433551,0.0004687235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0717696,0.009914109,0.003378848,0.003209231,0.0005987968,0.0005429292,0.0007266006,0.0007568786,0.8130852,0.002884781,0.009274293,0.08385872],"study_design_scores_gemma":[0.007742987,0.2002776,0.0211425,0.0007815528,0.0007934543,0.001979567,0.0003140186,0.002160204,0.6632365,0.000919338,0.1005297,0.0001225127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8668401,0.03240346,0.03682769,0.002972036,0.0008441795,0.0114677,0.0114694,0.00107105,0.03610433],"genre_scores_gemma":[0.9165645,0.01448354,0.02504106,0.0009766752,0.0004376468,0.007456779,0.01527962,0.0002474337,0.01951282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01053198,"threshold_uncertainty_score":0.05569911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.086690387810656,"score_gpt":0.3224368834685817,"score_spread":0.2357464956579257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}