{"id":"W4327684383","doi":"10.1093/jnci/djad043","title":"Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions","year":2023,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research and Materiel Command; National Cancer Institute; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; School of Public Health, Imperial College London; Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de Recerca; Leeds Biomedical Research Centre; Russian Academy of Sciences; Cancer Council Victoria; Canadian Cancer Society Research Institute; Manchester Biomedical Research Centre; University of California, San Francisco; University of Texas MD Anderson Cancer Center; National Institute for Health and Care Research; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Wereld Kanker Onderzoek Fonds; Compagnia di San Paolo; Yale University; Xunta de Galicia; Xarxa de Bancs de Tumors de Catalunya; Innovative Medicines Initiative; Pomorski Uniwersytet Medyczny W Szczecinie; National Health and Medical Research Council; Deutsche Krebshilfe; University of Illinois at Urbana-Champaign; Associazione Italiana per la Ricerca sul Cancro; Ligue Contre le Cancer; Canadian Institutes of Health Research; European Commission; Knut och Alice Wallenbergs Stiftelse; Vanderbilt University; Korea Health Industry Development Institute; Hellenic Health Foundation; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; Ministry of Health, Labour and Welfare; Ministerstvo Zdravotnictví Ceské Republiky; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; American Cancer Society; Radboud Universiteit; Cancer Australia; Vetenskapsrådet; Prostate Cancer Foundation of Australia; Fundação de Amparo à Pesquisa do Estado de São Paulo; Peter MacCallum Foundation; Cancer Institute NSW; NIHR Cambridge Biomedical Research Centre; University College London; NIHR Imperial Biomedical Research Centre; McGill University; Generalitat de Catalunya; Imperial College London; Genome Canada; Fred C. and Katherine B. Andersen Foundation; Food Standards Agency; Helse Vest; Department of Health and Social Care; U.S. Public Health Service; ZonMw; National Institute of Dental and Craniofacial Research; University of Cambridge; Government of Canada; Georgia Clinical and Translational Science Alliance; Chonnam National University; Royal Marsden NHS Foundation Trust; Centres de Recerca de Catalunya; University of South Florida; Ovarian Cancer Australia; Cancer Research Society; U.S. Department of Defense; NordForsk; World Cancer Research Fund; BC Cancer Foundation; Cancer Care Ontario; Wellcome Trust; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; Centre International de Recherche sur le Cancer; Deutsches Krebsforschungszentrum; Rutgers Cancer Institute of New Jersey; Cancer Research Institute; Medical Research Council; Mayo Foundation for Medical Education and Research; Ontario Ministry of Research and Innovation; Duncan Family Institute for Cancer Prevention and Risk Assessment; World Cancer Research Fund International; Oak Foundation; Prostate Cancer Foundation; Lon V. Smith Foundation; Pancreatic Cancer UK; Breast Cancer Research Foundation; Minnesota Ovarian Cancer Alliance; Wayne State University; Cancer Research UK; World Health Organization; Kaiser Permanente; Stockholms Läns Landsting; Norges Forskningsråd; Florida Department of Health; National Institutes of Health; Division of Cancer Prevention, National Cancer Institute; Cancer Research Foundation in Northern Sweden; Petrus och Augusta Hedlunds Stiftelse; University of Pittsburgh; Pelotonia; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Moffitt Cancer Center; National Cancer Research Institute; U.S. Department of Health and Human Services; Ministerio de Economía y Competitividad; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; California Department of Public Health; Rosetrees Trust; Damon Runyon Cancer Research Foundation; Institut Gustave-Roussy; Grantová Agentura České Republiky; Mike and Josie Harper Cancer Research Institute","keywords":"Genome-wide association study; Cancer; Biology; Genetic association; Prostate cancer; Heritability; Breast cancer; Colorectal cancer; Genetics; Single-nucleotide polymorphism; Oncology; Medicine; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003048989,0.0005639715,0.0008419373,0.002107252,0.0004584095,0.0008620954,0.0005372979,0.0004816697,0.002229823],"category_scores_gemma":[0.006387135,0.0003463576,0.0016223,0.002873282,0.0006589775,0.0004340872,0.001291684,0.0008785697,0.000199684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003081738,"about_ca_system_score_gemma":0.0005257835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002616283,"about_ca_topic_score_gemma":0.003593446,"domain_scores_codex":[0.9980651,0.0004358175,0.0001509389,0.0008824707,0.0002649227,0.0002006533],"domain_scores_gemma":[0.9923797,0.004040719,0.001979608,0.001017069,0.0003408966,0.0002419731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002636308,0.00003797454,0.9691207,0.0001764651,0.003858539,0.0003659317,0.0002474646,0.001713852,0.01189257,0.0005760055,0.0003379591,0.0114089],"study_design_scores_gemma":[0.00002270922,0.0000538261,0.9938128,0.00002448166,0.0008945849,0.0004359027,0.0001096788,0.001429927,0.001185903,0.001305158,0.0007115594,0.00001343953],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845256,0.002935137,0.009565035,0.0002040924,0.00002324248,0.00002200247,0.001849484,0.0001336745,0.0007417861],"genre_scores_gemma":[0.9963644,0.0004722144,0.001949345,0.0000721537,0.00002074447,0.00001820869,0.001002504,0.0000313749,0.00006895758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003048989,"threshold_uncertainty_score":0.01612478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110919079142565,"score_gpt":0.389079321515388,"score_spread":0.2779874136011315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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