{"id":"W4327702808","doi":"10.1016/j.toxlet.2023.03.005","title":"Hepatotoxicity of polymeric proanthocyanidins is caused by translocation of bacterial lipopolysaccharides through impaired gut epithelium","year":2023,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Occludin; Akkermansia muciniphila; Chemistry; Lipopolysaccharide; Gut flora; Akkermansia; Proanthocyanidin; Bifidobacterium; Tight junction; Biochemistry; Microbiology; Toxicity; Bioavailability; Pharmacology; Lactobacillus; Biology; Endocrinology; Antioxidant; Polyphenol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002862822,0.0005061306,0.0003289281,0.0003136984,0.0001781496,0.0003014527,0.0001844441,0.0004855481,0.001236226],"category_scores_gemma":[0.0002956858,0.0003009611,0.0003472968,0.0001716017,0.0005457958,0.0003408073,0.0003961769,0.0007992781,0.0002803146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162791,"about_ca_system_score_gemma":0.0001988236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002270499,"about_ca_topic_score_gemma":0.0001786746,"domain_scores_codex":[0.9996947,0.0001124373,0.00002354683,0.00004882392,0.00005169996,0.00006868985],"domain_scores_gemma":[0.9996281,0.00004757762,0.0001407834,0.00007211656,0.0000298177,0.0000817388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002129608,0.00004971989,0.001004398,0.00003755668,0.00001238237,0.0003528452,0.00001316652,0.00004004757,0.9950512,0.00008343988,0.00003601572,0.001189721],"study_design_scores_gemma":[0.0001225028,0.001648607,0.04166096,0.0000126573,0.00004533286,0.002450493,0.0001056023,0.0008646345,0.9518698,0.0003687095,0.0008382931,0.0000122748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964,0.0007429262,0.002047584,0.0001482335,0.00002936797,0.00001345441,0.00007200807,0.00005876982,0.0004875822],"genre_scores_gemma":[0.9981546,0.0003086424,0.000731692,0.00004077576,0.0000105446,0.00001079051,0.0000646817,0.00001108882,0.000667171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001236226,"threshold_uncertainty_score":0.004135609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547198906402982,"score_gpt":0.2672525983592055,"score_spread":0.2517806092951757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}