{"id":"W4327702808","doi":"10.1016/j.toxlet.2023.03.005","title":"Hepatotoxicity of polymeric proanthocyanidins is caused by translocation of bacterial lipopolysaccharides through impaired gut epithelium","year":2023,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Occludin; Akkermansia muciniphila; Chemistry; Lipopolysaccharide; Gut flora; Akkermansia; Proanthocyanidin; Bifidobacterium; Tight junction; Biochemistry; Microbiology; Toxicity; Bioavailability; Pharmacology; Lactobacillus; Biology; Endocrinology; Antioxidant; Polyphenol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780951,0.0001736009,0.0003252414,0.00007269162,0.00006455967,0.000004699283,0.0002079811,0.000234793,0.00009356949],"category_scores_gemma":[0.00002426911,0.000174187,0.0001222597,0.000230919,0.0002551861,0.000007391725,0.00005064827,0.00008681522,0.00001179863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002027168,"about_ca_system_score_gemma":0.0001233404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001926214,"about_ca_topic_score_gemma":0.00005321353,"domain_scores_codex":[0.9986802,0.000123334,0.0004148299,0.0003358814,0.00009201962,0.0003536843],"domain_scores_gemma":[0.9993491,0.00002090805,0.0002234089,0.0003107005,0.00004153209,0.00005436414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001301217,0.0001025229,0.001410149,0.00006846811,0.00007816121,0.000001478023,0.0006926009,0.000003474124,0.9759893,0.00001128537,0.02120751,0.0003049703],"study_design_scores_gemma":[0.0007291383,0.0004054625,0.005104351,0.00001307733,0.00002439779,0.000005446727,0.00007476038,0.00001606482,0.9916821,0.00001017412,0.001783113,0.0001519179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944302,0.0002043719,0.0003999188,0.004049961,0.0002697129,0.0003414838,0.00025674,0.00002897313,0.00001866975],"genre_scores_gemma":[0.9964727,0.0003599763,0.0001608555,0.00249848,0.00009823899,0.00002710349,0.0002773971,0.00002655768,0.0000787442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0194244,"threshold_uncertainty_score":0.710314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547198906402982,"score_gpt":0.2672525983592055,"score_spread":0.2517806092951757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}