{"id":"W4327704773","doi":"10.1016/s1473-3099(23)00062-2","title":"Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data","year":2023,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Respiratory viral infections research","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McGill University Health Centre","funders":"Sanofi; AstraZeneca","keywords":"Virology; Virus; Fusion protein; Glycoprotein; GenBank; Biology; Pneumovirinae; Conserved sequence; Paramyxoviridae; Peptide sequence; Genetics; Recombinant DNA; Viral disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438552,0.0001957975,0.0007177024,0.001273149,0.0003022225,0.00009891379,0.0002853203,0.00007448711,0.0001126952],"category_scores_gemma":[0.00119638,0.0001568672,0.00007643769,0.004446462,0.0002211649,0.000491312,0.0003634711,0.0003229878,0.00003725442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479219,"about_ca_system_score_gemma":0.0004051864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00317463,"about_ca_topic_score_gemma":0.007790759,"domain_scores_codex":[0.997238,0.0006831067,0.0005791138,0.0005312196,0.0006262501,0.0003423278],"domain_scores_gemma":[0.9977114,0.0005111888,0.0002078751,0.001232848,0.0001962769,0.0001403746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002263524,0.0002531015,0.9865861,0.00007657657,0.0004785196,0.00003749955,0.0001656172,0.0005024269,0.008767048,0.00002882372,0.0004050073,0.002472921],"study_design_scores_gemma":[0.001719943,0.0005150171,0.9910909,0.00008171784,0.0009973109,0.000001338738,0.0002093206,0.004570199,0.0001972692,0.00006451106,0.0004067963,0.0001456738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973934,0.0001891607,0.00003463609,0.0002033722,0.00005655329,0.001146828,0.0007237312,0.0001569419,0.00009533477],"genre_scores_gemma":[0.9979658,0.00007250665,0.000009576655,0.0002845466,0.0003611378,0.0001220178,0.001113421,0.00002582122,0.00004514721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008569779,"threshold_uncertainty_score":0.6396857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2565471512292255,"score_gpt":0.4309851242018139,"score_spread":0.1744379729725884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}