{"id":"W4327724279","doi":"10.1093/braincomms/fcad074","title":"Association of biological sex with clinical outcomes and biomarkers of Alzheimer’s disease in adults with Down syndrome","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Vetenskapsrådet; European Commission; Familjen Erling-Perssons Stiftelse; Hjärnfonden; Fondation Jérôme Lejeune; University College London; Global Brain Health Institute; Generalitat de Catalunya; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Instituto de Salud Carlos III; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Down Syndrome Research Foundation; NIHR Cambridge Biomedical Research Centre; Alzheimer's Drug Discovery Foundation; Alzheimerfonden; Fundació la Marató de TV3; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas","keywords":"Medicine; Disease; Biomarker; Population; Down syndrome; Cognitive decline; Alzheimer's disease; Internal medicine; Oncology; Pediatrics; Gerontology; Dementia; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007321377,0.0002269663,0.0002511463,0.0004758697,0.0002129692,0.0004082599,0.0001988416,0.0003080008,0.001443957],"category_scores_gemma":[0.002729679,0.0001348144,0.0002531091,0.0003538648,0.0001794593,0.0002328701,0.0003106813,0.000280416,0.0001637975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243582,"about_ca_system_score_gemma":0.00008945206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002140096,"about_ca_topic_score_gemma":0.001877995,"domain_scores_codex":[0.9996363,0.0001135861,0.00004472918,0.0001050711,0.00006140656,0.00003896336],"domain_scores_gemma":[0.9988195,0.0003769084,0.0004459554,0.0001140429,0.0001299363,0.0001136337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001877194,0.00001305721,0.9986728,0.000003941522,0.00002774989,0.00003615263,0.00007304452,0.00001391894,0.0001493343,0.00001265948,0.00001999058,0.0007895289],"study_design_scores_gemma":[0.000004107994,0.0000810233,0.9994707,0.000002766617,0.000009821933,0.0001406422,0.00009297104,0.00008311289,0.00004054325,0.00002103779,0.00005212384,0.000001297619],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99934,0.000226743,0.00007294131,0.00001617119,0.000004425263,0.000002376969,0.0001317173,0.000001187191,0.0002044761],"genre_scores_gemma":[0.9996933,0.00003566474,0.00003700082,0.000007972016,0.000003629642,0.000002939604,0.00009775639,7.23628e-7,0.0001210651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140096,"threshold_uncertainty_score":0.00483048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1192135561918933,"score_gpt":0.4057387313378842,"score_spread":0.2865251751459909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}