{"id":"W4327724279","doi":"10.1093/braincomms/fcad074","title":"Association of biological sex with clinical outcomes and biomarkers of Alzheimer’s disease in adults with Down syndrome","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Vetenskapsrådet; European Commission; Familjen Erling-Perssons Stiftelse; Hjärnfonden; Fondation Jérôme Lejeune; University College London; Global Brain Health Institute; Generalitat de Catalunya; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Instituto de Salud Carlos III; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Down Syndrome Research Foundation; NIHR Cambridge Biomedical Research Centre; Alzheimer's Drug Discovery Foundation; Alzheimerfonden; Fundació la Marató de TV3; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas","keywords":"Medicine; Disease; Biomarker; Population; Down syndrome; Cognitive decline; Alzheimer's disease; Internal medicine; Oncology; Pediatrics; Gerontology; Dementia; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116465,0.000090423,0.0003910775,0.000176489,0.00004469329,0.000005801017,0.0002273162,0.00008310495,0.00007628828],"category_scores_gemma":[0.002357178,0.00005952278,0.00005971385,0.0007132964,0.0006250712,0.00004948286,0.0001921859,0.0002058113,0.00001898896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002862991,"about_ca_system_score_gemma":0.0001350733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002461484,"about_ca_topic_score_gemma":0.0002177485,"domain_scores_codex":[0.9985821,0.0003621274,0.0004489749,0.0001897636,0.0002506924,0.0001663323],"domain_scores_gemma":[0.9966606,0.002065488,0.0001117169,0.0008971731,0.0001373881,0.0001276209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00036486,0.0004908302,0.9956108,0.00006094209,0.0003043553,0.000002713121,0.0003236229,0.00000104193,0.00003112998,0.00007340957,0.001297043,0.001439269],"study_design_scores_gemma":[0.00141779,0.0008093183,0.9959694,0.0002063828,0.00006676147,0.000006757019,0.000568343,0.0005137543,0.000008987154,0.00007362385,0.0002911777,0.00006773527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845032,0.0001675659,0.000003902517,0.01354889,0.000005064487,0.0005565608,0.00004962915,0.00003232641,0.001132855],"genre_scores_gemma":[0.998476,0.0004295056,0.0004069245,0.00009414907,0.000002149735,0.00005701392,0.0001387392,0.000009422484,0.0003861289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01397277,"threshold_uncertainty_score":0.2821933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1192135561918933,"score_gpt":0.4057387313378842,"score_spread":0.2865251751459909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}