{"id":"W4327732028","doi":"10.21203/rs.3.rs-2616340/v1","title":"Autophagy-enhancing ATG16L1 polymorphism improves clinical outcomes and promotes superior T-cell immunity in chronic HIV-1 infection","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Rijksinstituut voor Volksgezondheid en Milieu; Stichting Sanquin Bloedvoorziening; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Universiteit van Amsterdam; ZonMw; Amsterdam University Medical Centers","keywords":"Autophagy; ATG16L1; Immunity; Human immunodeficiency virus (HIV); Immunology; Cell; Medicine; Biology; Virology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000185292,0.0001925878,0.0003542191,0.0001636319,0.0001240587,0.0002449679,0.00008929482,0.0002084488,0.001580101],"category_scores_gemma":[0.0001800615,0.000068372,0.0001207861,0.0001193689,0.0001837229,0.00006837206,0.0001466672,0.000396441,0.0002831185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007272828,"about_ca_system_score_gemma":0.00009642213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001470296,"about_ca_topic_score_gemma":0.0001516305,"domain_scores_codex":[0.9999409,0.0000162406,0.000006546021,0.00001484735,0.000009023632,0.00001246888],"domain_scores_gemma":[0.9998828,0.00002420307,0.00002622962,0.00001634335,0.000009831419,0.00004061524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006138448,0.000596617,0.0230405,0.00006626957,0.00004590954,0.000371793,0.00006452894,0.0001197492,0.9511184,0.00008062103,0.000351369,0.01800589],"study_design_scores_gemma":[0.0006802691,0.01883874,0.433975,0.00005273207,0.0003026582,0.007332433,0.0002429852,0.002463772,0.5298817,0.0006928119,0.005505596,0.00003128735],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986695,0.0002798573,0.0004222372,0.0000546124,0.00001568782,0.000009080747,0.000147988,0.00002558389,0.0003753384],"genre_scores_gemma":[0.9985425,0.0001109914,0.0003719444,0.00003675265,0.00001383204,0.000008933594,0.0001850645,0.00001053661,0.0007194981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580101,"threshold_uncertainty_score":0.005285919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07138882411144398,"score_gpt":0.4053530664378116,"score_spread":0.3339642423263676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}