{"id":"W4327811353","doi":"10.1111/cts.13514","title":"Pharmacokinetics of intranasal amiloride in healthy volunteers","year":2023,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Olfactory and Sensory Function Studies","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Centre of Excellence for Child and Youth Mental Health; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Nasal administration; Amiloride; Medicine; Pharmacology; Pharmacokinetics; Anxiety; Psychiatry; Sodium; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007168376,0.00005566143,0.0001264381,0.0001226547,0.0001364952,0.000009069841,0.0001117796,0.00002426318,0.00002656985],"category_scores_gemma":[0.0003773276,0.00004631021,0.00003373002,0.0009974175,0.001483047,0.0001456272,0.00002110721,0.0001249647,0.00001731582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002530945,"about_ca_system_score_gemma":0.00006503444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004531406,"about_ca_topic_score_gemma":0.000009351852,"domain_scores_codex":[0.9988238,0.00005609623,0.000352807,0.0002938511,0.0003013569,0.0001720722],"domain_scores_gemma":[0.9990937,0.0006953951,0.00003521303,0.00005787546,0.00003372622,0.00008409521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009714408,0.0003106748,0.8428004,0.00006544987,0.000006916106,0.00002092529,0.001421795,0.002592588,0.0909439,0.0296561,0.000283619,0.03092625],"study_design_scores_gemma":[0.0009658351,0.0001539164,0.9775855,0.00001010895,0.000004142693,0.000002089483,0.00007233628,0.01103845,0.004278975,0.003002904,0.002791209,0.00009452204],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959151,0.00002205819,0.0001074542,0.002541025,0.0004769157,0.00007744144,0.00001401342,0.00002712637,0.0008189057],"genre_scores_gemma":[0.9990907,0.0003074576,0.00005093488,0.0004500831,0.00004685094,0.000001989797,5.366365e-7,0.000002236792,0.00004921234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1347852,"threshold_uncertainty_score":0.5464347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2998012662352414,"score_gpt":0.4139924891989067,"score_spread":0.1141912229636653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}