{"id":"W4327811432","doi":"10.1007/s10815-023-02773-4","title":"Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts","year":2023,"lang":"en","type":"article","venue":"Journal of Assisted Reproduction and Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Executive Agency; Carraresi Foundation; Università degli Studi di Milano","keywords":"Cell biology; Spheroid; Epigenetics; Biology; Phenotype; Embryonic stem cell; Cell culture; Cellular differentiation; Cell type; Cell; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004237888,0.0001172588,0.0002021655,0.0001934875,0.00009199501,0.0000442425,0.0001015833,0.0001169455,0.000004410704],"category_scores_gemma":[0.000195204,0.0001106349,0.00005899867,0.0002175664,0.00007521926,0.000009368917,0.0001295605,0.0001200924,0.000001578032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001249911,"about_ca_system_score_gemma":0.00004491383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008347513,"about_ca_topic_score_gemma":0.00001727343,"domain_scores_codex":[0.9986466,0.0001384115,0.0004527152,0.0003214913,0.0002755289,0.0001653042],"domain_scores_gemma":[0.9989067,0.00001670924,0.0002301886,0.0002338691,0.0004691962,0.0001433267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025955,0.00005567319,0.002637685,0.0000316017,0.00007023611,0.000005351856,0.0000778448,0.0005152486,0.9836395,0.000009887432,0.0004352035,0.01241919],"study_design_scores_gemma":[0.0007076612,0.0009065161,0.1368102,0.00005570673,0.00003588623,0.00009730747,0.0001154745,0.0002836709,0.8593959,0.0001470312,0.001326537,0.0001180785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960299,0.001039988,0.001740423,0.0008104685,0.0002335285,0.0001160734,0.000008886852,0.000005848296,0.00001489264],"genre_scores_gemma":[0.995055,0.001653112,0.002545516,0.00003603443,0.0003369701,0.000001863575,0.0000258701,0.00001789818,0.0003277037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1341725,"threshold_uncertainty_score":0.4511559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132269770336088,"score_gpt":0.2973994420430459,"score_spread":0.276076744339685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}