{"id":"W4327811432","doi":"10.1007/s10815-023-02773-4","title":"Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts","year":2023,"lang":"en","type":"article","venue":"Journal of Assisted Reproduction and Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Executive Agency; Carraresi Foundation; Università degli Studi di Milano","keywords":"Cell biology; Spheroid; Epigenetics; Biology; Phenotype; Embryonic stem cell; Cell culture; Cellular differentiation; Cell type; Cell; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810032,0.0003307154,0.0001618855,0.0001873891,0.00009929276,0.0002345995,0.0001643891,0.000239723,0.0006060569],"category_scores_gemma":[0.00009528017,0.0001568405,0.0002645759,0.00009327606,0.0001101801,0.0001352626,0.0002507771,0.000360718,0.0002613488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010016,"about_ca_system_score_gemma":0.0001182798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002020745,"about_ca_topic_score_gemma":0.0007073106,"domain_scores_codex":[0.9998461,0.00001836621,0.00002145571,0.00003544475,0.00005975439,0.00001892117],"domain_scores_gemma":[0.9999347,0.00001285931,0.00001685697,0.00001590255,0.000008683898,0.00001101618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009178349,0.000009636935,0.00006597203,0.00001964145,0.00000271482,0.00003799175,0.00000667401,0.00004385925,0.9984031,0.00003161942,0.00001672571,0.001352881],"study_design_scores_gemma":[0.000004425513,0.00009095242,0.000977029,0.000002650371,0.000008037097,0.0001383207,0.000009030502,0.0003519501,0.9961839,0.00001229604,0.002218109,0.000003325163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9405601,0.004160475,0.04855923,0.0001740911,0.0002078675,0.0003413284,0.0005440502,0.0001845423,0.005268335],"genre_scores_gemma":[0.9592169,0.002232054,0.03246459,0.0001043507,0.00003766132,0.0002154281,0.0005222031,0.00003598088,0.005170876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006060569,"threshold_uncertainty_score":0.002027452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132269770336088,"score_gpt":0.2973994420430459,"score_spread":0.276076744339685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}