{"id":"W4327843980","doi":"10.1101/2023.03.17.533092","title":"Antibodies generated <i>in vitro</i> and <i>in vivo</i> elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"BrisSynBio; Biotechnology and Biological Sciences Research Council; Medical Research Council; Bundesministerium für Bildung und Forschung; Weizmann Institute of Science; Max-Planck-Gesellschaft; U.S. Food and Drug Administration; Engineering and Physical Sciences Research Council; Heidelberg Biosciences International Graduate School; UK Research and Innovation; Deutsche Forschungsgemeinschaft; University of Bristol; Hamilton Health Sciences Foundation; British Society for Antimicrobial Chemotherapy; Wellcome Trust","keywords":"Epitope; Virology; In vitro; Coronavirus disease 2019 (COVID-19); Antibody; In vivo; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Chemistry; Computational biology; Biology; Infectious disease (medical specialty); Immunology; Medicine; Biochemistry; Genetics; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001681083,0.0002864228,0.00009958197,0.00009186073,0.00008368615,0.0001654107,0.0001603147,0.0002237572,0.001216186],"category_scores_gemma":[0.00009137412,0.0000936636,0.0001815922,0.00004696358,0.0001194022,0.0001291301,0.0001059067,0.0002988116,0.0003868555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002360908,"about_ca_system_score_gemma":0.0001559293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005229847,"about_ca_topic_score_gemma":0.0006123541,"domain_scores_codex":[0.9999338,0.00001243011,0.000005012687,0.00001347237,0.00001837919,0.00001686135],"domain_scores_gemma":[0.9999644,0.000005443551,0.000009794655,0.000003249876,0.00000904685,0.000008117685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004879907,0.00004224041,0.0001358556,0.00003012838,0.000003064116,0.0000189255,0.000009254807,0.0005397967,0.9976557,0.0001625668,0.00006925428,0.001284446],"study_design_scores_gemma":[0.00001133726,0.0004287116,0.000451362,0.000004422212,0.000008448787,0.00005908318,0.000008869533,0.001892891,0.9942075,0.00004455305,0.00288034,0.000002443112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971338,0.0008286306,0.02177583,0.0002088948,0.00005409517,0.0001559746,0.0002960037,0.00006729684,0.005275401],"genre_scores_gemma":[0.9835924,0.000490393,0.01248166,0.0001248923,0.000007943945,0.00004985025,0.0003759571,0.00002156669,0.002855279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216186,"threshold_uncertainty_score":0.004068494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04482472934754775,"score_gpt":0.2980202393537351,"score_spread":0.2531955100061873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}