{"id":"W4327856879","doi":"10.1017/9781108917919.006","title":"Clinical Trial Simulations","year":2023,"lang":"en","type":"book-chapter","venue":"Cambridge University Press eBooks","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Clinical trial; Adaptive design; Computer science; Medical physics; Quality (philosophy); Clinical study design; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001867944,0.000474876,0.001472977,0.0001855879,0.0001944359,0.00004788928,0.0007671514,0.001259808,0.00005028896],"category_scores_gemma":[0.01937349,0.0005252188,0.0008671209,0.00001808374,0.0006002575,0.00004073471,0.0006822216,0.001316818,0.0001421147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286012,"about_ca_system_score_gemma":0.0001987326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001257209,"about_ca_topic_score_gemma":0.000001776461,"domain_scores_codex":[0.9962284,0.0006244761,0.001303668,0.0008913382,0.0005714738,0.0003806521],"domain_scores_gemma":[0.9427448,0.05468949,0.0007791786,0.001169047,0.0002737146,0.0003437653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003663208,0.00004148996,5.247725e-7,0.00008112299,0.0003391835,0.0002172378,0.000005234999,8.377281e-7,5.521218e-7,0.9154255,0.07718688,0.003038201],"study_design_scores_gemma":[0.02535871,0.0004179552,0.00000479025,0.0003178061,0.00148651,0.0000024242,0.000007446653,0.0001751354,0.000007694795,0.11896,0.8524709,0.0007905919],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.00004784786,0.000005771024,0.01218384,0.0000254913,0.002897859,0.001570737,0.001768283,0.0005655394,0.9809346],"genre_scores_gemma":[0.00003591492,0.00005198608,0.04748067,0.00005532155,0.001449904,0.00000156675,0.00002341496,0.0001463023,0.9507549],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.7964655,"threshold_uncertainty_score":0.9997199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6617060423124212,"score_gpt":0.5112509063982514,"score_spread":0.1504551359141698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}