{"id":"W4327857423","doi":"10.1038/s41541-023-00635-9","title":"Hepatitis C virus E1 and modified E2 delivered from an mRNA vaccine induces protective immunity","year":2023,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Hepatitis C virus research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Alberta; Burnet Institute; Saint Louis University; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Johns Hopkins University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Virology; Immunogenicity; Vaccination; Hepatitis C virus; Immune system; Vaccinia; Epitope; Virus; Immunology; Antibody; Biology; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004135945,0.000302243,0.0005606724,0.0003926012,0.0002843533,0.00008132985,0.0002476098,0.0002327955,0.0005312787],"category_scores_gemma":[0.001175628,0.0002654204,0.00007390373,0.0008191638,0.000036969,0.0002933646,0.0002697263,0.0005892458,0.0002719047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001072428,"about_ca_system_score_gemma":0.0001460357,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06525467,"about_ca_topic_score_gemma":0.01130802,"domain_scores_codex":[0.9977401,0.0002766517,0.0003965625,0.000565182,0.00049192,0.0005295862],"domain_scores_gemma":[0.9981257,0.0002439479,0.00009810946,0.0006851526,0.0004727059,0.0003743595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001657798,0.0004908738,0.629432,0.0002044592,0.0005378945,0.0004587447,0.003019186,0.00001805971,0.1733824,0.0001036481,0.009375508,0.1813195],"study_design_scores_gemma":[0.003154742,0.0009329699,0.956843,0.000127806,0.00007570935,0.000009261064,0.0002084977,0.003558664,0.03188984,0.001503541,0.001381307,0.000314636],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951719,0.0005249512,0.00002741367,0.0008263921,0.0001829289,0.001153545,0.0001900057,0.0004061891,0.00151666],"genre_scores_gemma":[0.9938694,0.004189181,0.0002473197,0.000239728,0.0004753852,0.0002113624,0.0002876116,0.00007083458,0.0004091856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3274111,"threshold_uncertainty_score":0.9999798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04937162581411508,"score_gpt":0.3390841122591961,"score_spread":0.289712486445081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}