{"id":"W4327857423","doi":"10.1038/s41541-023-00635-9","title":"Hepatitis C virus E1 and modified E2 delivered from an mRNA vaccine induces protective immunity","year":2023,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Hepatitis C virus research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Alberta; Burnet Institute; Saint Louis University; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Johns Hopkins University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Virology; Immunogenicity; Vaccination; Hepatitis C virus; Immune system; Vaccinia; Epitope; Virus; Immunology; Antibody; Biology; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109451,0.0003830425,0.0001934897,0.0001117113,0.00006226216,0.0001795877,0.00008011352,0.0002585442,0.001074862],"category_scores_gemma":[0.0001013635,0.00008492831,0.0001612402,0.00005885227,0.0001350953,0.0001255375,0.0001424526,0.0003426364,0.0002294148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000116249,"about_ca_system_score_gemma":0.00009014611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000129246,"about_ca_topic_score_gemma":0.0001628547,"domain_scores_codex":[0.9999088,0.0000172177,0.000007059642,0.00001933873,0.00002201459,0.00002549914],"domain_scores_gemma":[0.9999435,0.00001228284,0.00001485812,0.000007214334,0.00001037877,0.00001174682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074009,0.00004432662,0.00008395085,0.00002657365,0.000002870521,0.00001664468,0.000004413585,0.00005062926,0.9988798,0.00002095086,0.00001209211,0.0007502279],"study_design_scores_gemma":[0.00002571588,0.001938606,0.002222647,0.000007232587,0.00001592307,0.0001732287,0.00001328949,0.0007188098,0.9934881,0.00002335801,0.001370455,0.00000269756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974816,0.0004448953,0.00121513,0.00002941817,0.00002711851,0.00002385851,0.0000605961,0.00003053573,0.0006868164],"genre_scores_gemma":[0.9967875,0.00029576,0.0009722747,0.00003980487,0.00001180618,0.00002057164,0.0001805377,0.000008551262,0.001683122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001074862,"threshold_uncertainty_score":0.00359571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04937162581411508,"score_gpt":0.3390841122591961,"score_spread":0.289712486445081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}