{"id":"W4327859571","doi":"10.21203/rs.3.rs-2657360/v1","title":"Tumor Intrinsic Mechanisms of Antigen Escape to Anti-BCMA and Anti-GPRC5D Targeted Immunotherapies in Multiple Myeloma","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Terry Fox Foundation; Glenmark Pharmaceuticals; American Society of Hematology; Comprehensive Cancer Center, City of Hope; Rising Tide Foundation; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; Celgene; Leukemia and Lymphoma Society; Genentech; Deutsche Krebshilfe; Amgen; U.S. Food and Drug Administration; Multiple Myeloma Research Foundation","keywords":"Antigen; Chimeric antigen receptor; Multiple myeloma; Missense mutation; T-cell receptor; Cancer research; Biology; T cell; Immunology; Mutation; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003982459,0.0002162853,0.0003847101,0.0001980354,0.0001144143,0.0007061801,0.0002696547,0.0004451885,0.001823752],"category_scores_gemma":[0.0003451357,0.0001438892,0.0003221295,0.0001959977,0.0002722548,0.0004097139,0.0004352875,0.0009642315,0.0003441749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005548592,"about_ca_system_score_gemma":0.0003039548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002712513,"about_ca_topic_score_gemma":0.00023627,"domain_scores_codex":[0.9998019,0.00003885199,0.000006816894,0.00002733999,0.00005583995,0.00006919159],"domain_scores_gemma":[0.9999443,0.0000151644,0.00001332675,0.000008743766,0.000008878073,0.000009623134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002468146,0.0003493066,0.003513427,0.0008451119,0.0002049029,0.0006690775,0.0001743171,0.004229115,0.8653328,0.01955725,0.003948318,0.09870823],"study_design_scores_gemma":[0.0006496659,0.003635071,0.05003035,0.0001671294,0.0004016329,0.004112783,0.0003692226,0.02582917,0.820226,0.02196948,0.07254939,0.00006009279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9513411,0.02757224,0.0111843,0.00201377,0.0002322736,0.00006115035,0.000467833,0.0001608868,0.006966488],"genre_scores_gemma":[0.9880133,0.006194809,0.001633185,0.0002679425,0.00005813815,0.0000335852,0.0002182133,0.00002357468,0.003557239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001823752,"threshold_uncertainty_score":0.006101072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0745172393073209,"score_gpt":0.377754997091955,"score_spread":0.3032377577846341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}