{"id":"W4327860875","doi":"10.1101/2023.03.14.532707","title":"Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in <i>T. brucei</i>","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"University of Glasgow; European Commission; Wellcome Trust","keywords":"Flagellum; Biology; Gene knockdown; RNA interference; Trypanosoma brucei; Gene; Cytokinesis; Genetics; Cell biology; Effector; RNA; Cell division; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158091,0.0003546647,0.000381124,0.0004081137,0.0002386457,0.0003290714,0.000233978,0.0003696354,0.001469347],"category_scores_gemma":[0.0001889815,0.0001686865,0.0004004828,0.0002862541,0.0002263267,0.00009361289,0.0002160351,0.0004683685,0.001094634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003123906,"about_ca_system_score_gemma":0.0001986026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001527212,"about_ca_topic_score_gemma":0.003036681,"domain_scores_codex":[0.9998829,0.000007875517,0.00001082505,0.00003509209,0.00004363184,0.00001956275],"domain_scores_gemma":[0.9998331,0.00003415749,0.00006041797,0.00001382814,0.00002937897,0.00002911095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003018704,0.000004696538,0.0004162866,0.00004166607,0.000004287746,0.00006262487,0.00001031391,0.0000158356,0.9986368,0.00001668135,0.0001066247,0.0006539342],"study_design_scores_gemma":[0.00004480475,0.0002679631,0.0844918,0.00005966812,0.0001380568,0.001707205,0.00016119,0.001764365,0.8973382,0.00009148967,0.0139039,0.00003126048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753949,0.002144001,0.009222263,0.0003274264,0.00008327873,0.000114315,0.009248835,0.0006258594,0.002839225],"genre_scores_gemma":[0.9543168,0.001179436,0.01459579,0.0005287184,0.00003047931,0.0001739569,0.02177749,0.0004524897,0.006944811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527212,"threshold_uncertainty_score":0.004915416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04595760676829179,"score_gpt":0.2790085550447178,"score_spread":0.233050948276426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}