{"id":"W4327861548","doi":"10.1101/2023.03.17.532588","title":"Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"UK Dementia Research Institute; Fondation Leducq; Medical Research Council; Alzheimer's Society; Wellcome Trust","keywords":"Phenotype; Myeloid; Biology; Ontogeny; Neuroscience; Cell type; Cell; Microglia; Immune system; Stroke (engine); Immunology; Inflammation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001956398,0.0001287524,0.0002273564,0.0004421093,0.0002036787,0.0004645652,0.00009293433,0.0001558795,0.001457637],"category_scores_gemma":[0.0002093361,0.00009279857,0.0001138397,0.0002379706,0.0003304972,0.0002036488,0.0004479516,0.000379752,0.0003691365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001895934,"about_ca_system_score_gemma":0.0001974765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003034374,"about_ca_topic_score_gemma":0.0006490106,"domain_scores_codex":[0.9998946,0.0000139546,0.000007854862,0.00003101226,0.00002659032,0.00002592966],"domain_scores_gemma":[0.9998651,0.00002189291,0.00004714755,0.0000164708,0.00001997599,0.00002931741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002563991,0.00001884691,0.01472856,0.00005877567,0.00001884244,0.0002353479,0.0002057837,0.0002343514,0.971427,0.001013621,0.0002012676,0.01160122],"study_design_scores_gemma":[0.0000273292,0.000334115,0.5860165,0.00006033151,0.00008534884,0.003597634,0.001296707,0.003573336,0.3908242,0.004489616,0.009660502,0.00003437583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936789,0.000953138,0.003469359,0.00009120734,0.0000136315,0.00001086166,0.0002949012,0.00003406031,0.001453962],"genre_scores_gemma":[0.9959723,0.0006527647,0.001319666,0.00002571565,0.00001129656,0.00002365319,0.0003181505,0.00001918129,0.001657247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001457637,"threshold_uncertainty_score":0.004876256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02014845101218355,"score_gpt":0.226766729444967,"score_spread":0.2066182784327834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}