{"id":"W4327862357","doi":"10.1101/2023.03.17.532992","title":"BCL7 proteins, metazoan-specific subunits of the mammalian SWI/SNF complex, bind the nucleosome core particle","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Université de Strasbourg; Fondation pour la Recherche Médicale","keywords":"Nucleosome; SWI/SNF; Chromatin; DNA-binding protein; Mutation; Biology; DNA; Function (biology); Chromatin remodeling; Protein subunit; Cell biology; Chemistry; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006013169,0.0004248213,0.0004005818,0.0000459481,0.0002563475,0.0001037498,0.001134979,0.0003957497,0.00003511328],"category_scores_gemma":[0.0001276198,0.000302285,0.0002904757,0.0004223594,0.0003029916,0.000005458997,0.0009189494,0.0004785562,0.00004076131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006051293,"about_ca_system_score_gemma":0.0003780358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008335103,"about_ca_topic_score_gemma":0.00002104472,"domain_scores_codex":[0.9976278,0.0001775161,0.0005507689,0.0007595913,0.0004144326,0.0004698796],"domain_scores_gemma":[0.9968233,0.00002660881,0.0004613579,0.00217056,0.0003934217,0.0001247932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003616984,0.00006476535,0.00245862,0.0001742169,0.000158453,0.000003736454,0.00001379355,0.000359148,0.9947056,0.00027419,0.001745692,0.000005653365],"study_design_scores_gemma":[0.000459272,0.00006302591,0.06241466,0.0002177858,0.0001008563,4.814174e-8,0.0000163688,0.0005901001,0.912753,0.000009290181,0.02289576,0.0004797989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949976,0.001926732,0.0002189772,0.0006868797,0.0007821017,0.0009411488,0.0003483328,0.00008927967,0.00000891872],"genre_scores_gemma":[0.9978147,0.0004991058,0.0006092404,0.0001881811,0.0005039719,0.0001882721,0.000002157508,0.0001337273,0.00006065808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08195253,"threshold_uncertainty_score":0.9999429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04595113893657208,"score_gpt":0.245172089311374,"score_spread":0.1992209503748019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}