{"id":"W4327898893","doi":"10.1002/hbm.26269","title":"The use of hippocampal grading as a biomarker for preclinical and prodromal Alzheimer's disease","year":2023,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hippocampal formation; Alzheimer's disease; Dementia; Cognition; Cognitive decline; Neuroimaging; Psychology; Neuroscience; Hippocampal sclerosis; Clinical Dementia Rating; Biomarker; Medicine; Internal medicine; Disease; Cognitive impairment; Temporal lobe; Biology; Epilepsy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006537,0.0001007597,0.0001655859,0.0001320968,0.0003724339,0.00007174975,0.00007290344,0.00003372595,0.00004134266],"category_scores_gemma":[0.00140811,0.00007282789,0.000106254,0.000209917,0.0002355891,0.00008162805,0.0001107617,0.0000971421,0.00001172282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000100405,"about_ca_system_score_gemma":0.0000715912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007965751,"about_ca_topic_score_gemma":0.000002466934,"domain_scores_codex":[0.9987629,0.0001035122,0.0002686097,0.0002562365,0.0002740174,0.0003347237],"domain_scores_gemma":[0.9982811,0.00117899,0.0000644107,0.0001915221,0.00009920698,0.0001848013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002156629,0.0004336654,0.7752929,0.0008580507,0.001451231,0.0001883366,0.001305177,0.000001062016,0.06076727,0.006769565,0.05898472,0.09179138],"study_design_scores_gemma":[0.001417995,0.000304509,0.9666688,0.0002232077,0.000121673,0.000006182891,0.0002455632,0.002047027,0.00007832584,0.003000531,0.02579652,0.00008967821],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929674,0.0002083149,0.0001260227,0.004991121,0.00004717017,0.00130686,0.00001033854,0.00006214642,0.0002806326],"genre_scores_gemma":[0.9970729,0.00002409269,0.0001434758,0.0003242634,0.00008878509,0.0001824467,0.00004709856,0.00001981731,0.00209709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1913759,"threshold_uncertainty_score":0.2969835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2445213941087805,"score_gpt":0.4200180483090022,"score_spread":0.1754966542002217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}