{"id":"W4327910154","doi":"10.1093/oncolo/oyad022","title":"Atezolizumab Plus PEGPH20 Versus Chemotherapy in Advanced Pancreatic Ductal Adenocarcinoma and Gastric Cancer: MORPHEUS Phase Ib/II Umbrella Randomized Study Platform","year":2023,"lang":"en","type":"article","venue":"The Oncologist","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; F. Hoffmann-La Roche","keywords":"Atezolizumab; Medicine; Gemcitabine; Oncology; Internal medicine; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Cancer; Adverse effect; Adenocarcinoma; Phases of clinical research; Chemotherapy; Urology; Immunotherapy; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004540826,0.001747797,0.002423493,0.0005620029,0.0002743563,0.001238508,0.0008431299,0.001388994,0.006443317],"category_scores_gemma":[0.002973736,0.0005740145,0.002258942,0.0004701624,0.001019463,0.00102834,0.0008510788,0.002136179,0.0006912483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001016741,"about_ca_system_score_gemma":0.001008338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005931805,"about_ca_topic_score_gemma":0.001490516,"domain_scores_codex":[0.998181,0.001356394,0.00008167265,0.0001575919,0.00009287702,0.0001304846],"domain_scores_gemma":[0.9987046,0.0003292751,0.0004069651,0.0001149028,0.00006005988,0.0003843409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9818606,0.003024878,0.0006839877,0.0005761138,0.0009131728,0.00002437875,0.00001970042,0.0002960003,0.001175143,0.0001521379,0.0008259909,0.01044781],"study_design_scores_gemma":[0.958796,0.0370408,0.001473281,0.00005765349,0.0006390156,0.00003379546,0.00001509244,0.0005494199,0.0002595218,0.0001889996,0.0009361692,0.00001007326],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642999,0.01411095,0.001209001,0.00251735,0.001070329,0.009258443,0.002250838,0.0001833397,0.005099776],"genre_scores_gemma":[0.9723794,0.004713763,0.003177483,0.002551238,0.001108449,0.008998567,0.001826033,0.00004560763,0.005199574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006443317,"threshold_uncertainty_score":0.02401447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07993181896745435,"score_gpt":0.4131683534045474,"score_spread":0.333236534437093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}