{"id":"W4327913908","doi":"10.26508/lsa.202201419","title":"Structure-based design and characterization of Parkin-activating mutations","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; Canadian Institutes of Health Research; Parkinson Canada; Canada Research Chairs; Wellcome Trust; National Institutes of Health; University of Dundee","keywords":"Parkin; Ubiquitin ligase; PINK1; Mitophagy; Mutant; Mutation; Ubiquitin; Genetics; Biology; Cell biology; Parkinson's disease; Gene; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532488,0.0000713627,0.0001133951,0.00008829762,0.0001411291,0.00002164902,0.00006262552,0.0000204082,0.00002168171],"category_scores_gemma":[0.0001622672,0.00006124385,0.00001611056,0.0008452325,0.00016257,0.0001673757,0.00001582527,0.00003334314,0.000007868367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002226858,"about_ca_system_score_gemma":0.0002718231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003712306,"about_ca_topic_score_gemma":2.531511e-7,"domain_scores_codex":[0.9991953,0.00001604197,0.0001187585,0.0002297303,0.0002735558,0.0001665931],"domain_scores_gemma":[0.9995185,0.00004062313,0.00008893582,0.0001350277,0.00007925892,0.0001376568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004080498,0.00003814903,0.01764093,0.00004097008,0.000012725,0.00001021056,0.0001366079,0.0002571333,0.975284,0.0002215723,0.000006511636,0.006310385],"study_design_scores_gemma":[0.0005838209,0.00009525834,0.6728233,0.0000900769,0.0000231757,0.000001897737,0.00003319043,0.03552143,0.2902531,0.0002877312,0.0002161322,0.00007092968],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911501,0.00002369891,0.008072978,0.0003229128,0.00007428331,0.0002518983,0.00002080418,0.00004854258,0.0000347428],"genre_scores_gemma":[0.9924304,0.0000177031,0.00722487,0.0002084795,0.0000195158,0.00001701004,0.00002831475,0.000006684191,0.00004706156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6850309,"threshold_uncertainty_score":0.2497451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03759452550227461,"score_gpt":0.298523845138305,"score_spread":0.2609293196360304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}