{"id":"W4327940554","doi":"10.1016/j.cell.2023.02.027","title":"Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Biology; Human immunodeficiency virus (HIV); Base (topology); Virology; CD3; Severe combined immunodeficiency; Immunodeficiency; Cell biology; Genetics; Computational biology; Immunology; Gene; Immune system; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000336247,0.0004460009,0.0003257022,0.0004540328,0.0003157059,0.0005481121,0.0003581055,0.000638967,0.004107325],"category_scores_gemma":[0.000201662,0.0001843119,0.0003357524,0.0002603366,0.0004773981,0.000191849,0.0002951971,0.001214759,0.0009517813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057463,"about_ca_system_score_gemma":0.0002677035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006429318,"about_ca_topic_score_gemma":0.0005837982,"domain_scores_codex":[0.9997273,0.00006198171,0.00003236582,0.00005727557,0.00004980295,0.00007120505],"domain_scores_gemma":[0.9998228,0.00003992334,0.000041073,0.00004363588,0.00001239767,0.00004019895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003008753,0.00004185085,0.0001729202,0.00002966113,0.00001060896,0.0002097666,0.00003856841,0.0001337445,0.9960402,0.000670483,0.0002775718,0.002073732],"study_design_scores_gemma":[0.0000895862,0.0002322696,0.001400293,0.000007755476,0.00002984855,0.0008502117,0.00003664924,0.001211689,0.9860707,0.0002484609,0.009812988,0.000009622838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804122,0.00106639,0.008401322,0.0002763683,0.0001736168,0.0001079663,0.001997295,0.0009171614,0.006647591],"genre_scores_gemma":[0.993701,0.0002627758,0.002078107,0.00007228438,0.0000160019,0.00003817127,0.0007331746,0.00009413967,0.003004435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004107325,"threshold_uncertainty_score":0.01374036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06127085463604074,"score_gpt":0.3283310821094729,"score_spread":0.2670602274734321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}