{"id":"W4327940554","doi":"10.1016/j.cell.2023.02.027","title":"Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Biology; Human immunodeficiency virus (HIV); Base (topology); Virology; CD3; Severe combined immunodeficiency; Immunodeficiency; Cell biology; Genetics; Computational biology; Immunology; Gene; Immune system; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005126971,0.0001874691,0.0002910532,0.0002393528,0.000169682,0.00004131275,0.0001803136,0.0001439305,0.003722855],"category_scores_gemma":[0.00004965406,0.0001875463,0.000103712,0.0008850138,0.00006945391,0.000122498,0.0001079332,0.0004459207,0.0005194598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978808,"about_ca_system_score_gemma":0.0001132565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003272012,"about_ca_topic_score_gemma":0.00003180478,"domain_scores_codex":[0.9980882,0.000100068,0.0003882747,0.0004347621,0.0004728032,0.0005158254],"domain_scores_gemma":[0.9990919,0.00006071831,0.00008229018,0.0005625595,0.0001120295,0.00009049737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006956766,0.000218933,0.001586755,0.0001246342,0.000006870502,0.0001312417,0.002358553,0.0000779669,0.9557849,0.00001846355,0.0392233,0.000398842],"study_design_scores_gemma":[0.01004057,0.0009864075,0.009589081,0.0001468256,0.00004659873,0.00002453255,0.00177804,0.01066307,0.9398052,0.0002210763,0.02621194,0.0004867055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585028,0.000384176,0.00001608952,0.001017771,0.0003173885,0.0005471576,0.00001192211,0.0001436887,0.03905897],"genre_scores_gemma":[0.9272286,0.0001202804,0.0001986151,0.0003514731,0.0005497474,0.00004111967,0.0002788739,0.00006001804,0.07117127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0321123,"threshold_uncertainty_score":0.9971879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06127085463604074,"score_gpt":0.3283310821094729,"score_spread":0.2670602274734321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}