{"id":"W4327957106","doi":"10.1016/j.eclinm.2023.101909","title":"Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database","year":2023,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; European Regional Development Fund; Relander Foundation; Centro de Investigación Biomédica en Red de Cáncer; Instituto de Salud Carlos III; Syöpäsäätiö; Maag Lever Darm Stichting; Sigrid Juséliuksen Säätiö; Università degli Studi di Parma; Fundação de Amparo à Pesquisa do Estado de São Paulo; Emil Aaltosen Säätiö; Cancer Research UK; KWF Kankerbestrijding; Cancer Australia; Academy of Finland; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Kreftforeningen; Centres de Recerca de Catalunya; Jane ja Aatos Erkon Säätiö; Royal Melbourne Hospital; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institutes of Health; Parc Geneteg Cymru; Health and Care Research Wales; Deutsche Krebshilfe; Ministerio de Economía y Competitividad; Victorian Cancer Agency","keywords":"Medicine; Lynch syndrome; Cancer; Gene; Lifetime risk; Oncology; Database; DNA mismatch repair; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006847431,0.0001869732,0.0003352843,0.001071535,0.0002265026,0.0004121055,0.0003022939,0.0002742318,0.001538905],"category_scores_gemma":[0.001638119,0.0002266413,0.0005918265,0.001375884,0.0001458049,0.0003013148,0.0005306251,0.0002880388,0.000269208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003060163,"about_ca_system_score_gemma":0.0003348706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0146079,"about_ca_topic_score_gemma":0.01308158,"domain_scores_codex":[0.9995056,0.0001092072,0.00008920801,0.0001384025,0.00008435403,0.00007316451],"domain_scores_gemma":[0.9989632,0.0002024252,0.0004763996,0.0001108549,0.0001232694,0.0001238346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001273398,0.000006672209,0.9982879,0.00001741637,0.00006297154,0.0000657912,0.00003369775,0.0000554028,0.00009382464,0.0000135638,0.0003642239,0.0008711418],"study_design_scores_gemma":[0.000008550795,0.00003646775,0.9988484,0.00001547741,0.00004689394,0.0002369751,0.0001321472,0.0001060142,0.00006451731,0.00001324286,0.0004861495,0.000005073474],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980633,0.0006927605,0.000177366,0.00004910077,0.00001247524,0.00001236249,0.01787278,0.0000084872,0.0005416906],"genre_scores_gemma":[0.9843264,0.0004223334,0.0001581147,0.00002440041,0.00001027827,0.0000286666,0.01466453,0.000005322816,0.0003599388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0146079,"threshold_uncertainty_score":0.02904576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08260586665539496,"score_gpt":0.3709972169894223,"score_spread":0.2883913503340274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}