{"id":"W4327957106","doi":"10.1016/j.eclinm.2023.101909","title":"Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database","year":2023,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; European Regional Development Fund; Relander Foundation; Centro de Investigación Biomédica en Red de Cáncer; Instituto de Salud Carlos III; Syöpäsäätiö; Maag Lever Darm Stichting; Sigrid Juséliuksen Säätiö; Università degli Studi di Parma; Fundação de Amparo à Pesquisa do Estado de São Paulo; Emil Aaltosen Säätiö; Cancer Research UK; KWF Kankerbestrijding; Cancer Australia; Academy of Finland; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Kreftforeningen; Centres de Recerca de Catalunya; Jane ja Aatos Erkon Säätiö; Royal Melbourne Hospital; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institutes of Health; Parc Geneteg Cymru; Health and Care Research Wales; Deutsche Krebshilfe; Ministerio de Economía y Competitividad; Victorian Cancer Agency","keywords":"Medicine; Lynch syndrome; Cancer; Gene; Lifetime risk; Oncology; Database; DNA mismatch repair; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001553951,0.0002887782,0.0009489499,0.00007254023,0.00008203241,0.000009821395,0.0001132958,0.0001762254,0.00009094371],"category_scores_gemma":[0.002430542,0.0002007056,0.0001229313,0.0004760287,0.0003786794,0.00004716626,0.0001134973,0.000227843,9.130468e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538107,"about_ca_system_score_gemma":0.0002380374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005642029,"about_ca_topic_score_gemma":0.001691264,"domain_scores_codex":[0.9971734,0.0001618849,0.0009547201,0.0009173698,0.0004002388,0.0003923926],"domain_scores_gemma":[0.9965431,0.002002695,0.0003081974,0.0007928218,0.0001175304,0.0002356391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003513115,0.0001288647,0.9880384,0.00009829074,0.0005398267,0.0007235493,0.001368178,0.000002832413,0.004874069,7.558439e-7,0.002659737,0.001214196],"study_design_scores_gemma":[0.004336281,0.0008287533,0.9919943,0.0002060316,0.0003965911,0.0001018201,0.0001462173,0.0002390223,0.001048515,0.0002527015,0.0002685053,0.0001813043],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884704,0.00627753,0.00004090138,0.0008707508,0.0004251021,0.001954967,0.001858145,0.00007437264,0.00002778302],"genre_scores_gemma":[0.9883456,0.008256718,0.001055451,0.0002376189,0.0002153314,0.001301342,0.0003894251,0.00004944474,0.0001491152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00398497,"threshold_uncertainty_score":0.8529097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08260586665539496,"score_gpt":0.3709972169894223,"score_spread":0.2883913503340274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}