{"id":"W4327958877","doi":"10.1016/j.ekir.2023.02.631","title":"WCN23-1107 A PHASE 1/2 MULTICENTER STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMIS OF BION-1301 IN HEALTHY VOLUNTEERS AND ADULTS WITH IgA NEPHROPATHY","year":2023,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Chinook Regional Hospital","funders":"Novo Nordisk; AstraZeneca","keywords":"Medicine; Tolerability; Pharmacokinetics; Nephropathy; Phases of clinical research; Pharmacology; Internal medicine; Adverse effect; Clinical trial; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001574781,0.001503023,0.001473876,0.0003304519,0.0004072253,0.0007640197,0.0005892192,0.001126202,0.004467841],"category_scores_gemma":[0.0008392668,0.0004076757,0.0009281315,0.0002985223,0.0007646366,0.0005159454,0.00031367,0.002542131,0.001069496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006830003,"about_ca_system_score_gemma":0.001730551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001607571,"about_ca_topic_score_gemma":0.002823311,"domain_scores_codex":[0.9994733,0.0002643733,0.00002099522,0.00008934629,0.00006322659,0.00008883709],"domain_scores_gemma":[0.9992112,0.00009373479,0.0001129739,0.00005270496,0.00007198241,0.0004574523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6727709,0.1205669,0.01085735,0.0009598094,0.003627361,0.0004540655,0.000298293,0.002091993,0.07465941,0.000397319,0.009540495,0.1037761],"study_design_scores_gemma":[0.3498815,0.6256567,0.01467081,0.00003784452,0.000576865,0.0002782926,0.0000667072,0.0008203941,0.003537417,0.0001727991,0.004261179,0.00003936067],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989609,0.002462584,0.000537226,0.0003897677,0.0001616447,0.003031261,0.001697667,0.00010516,0.002005686],"genre_scores_gemma":[0.9831408,0.001802559,0.001605708,0.001442689,0.0001988675,0.00404843,0.002769299,0.00004671042,0.004944746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004467841,"threshold_uncertainty_score":0.0149464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274019661342978,"score_gpt":0.3266032784334961,"score_spread":0.3138630818200663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}