{"id":"W4327967417","doi":"10.3390/cancers15061849","title":"Advances in PARP Inhibitors for Prostate Cancer","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Pfizer Canada","keywords":"Olaparib; Medicine; Prostate cancer; Synthetic lethality; PARP inhibitor; Oncology; Population; Clinical trial; Cochrane Library; DNA repair; Internal medicine; Cancer; Bioinformatics; Poly ADP ribose polymerase; Randomized controlled trial; Biology; Polymerase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001423461,0.001045131,0.002032371,0.003462097,0.0002880863,0.001114883,0.0009514464,0.001041112,0.007195967],"category_scores_gemma":[0.001802058,0.0003585708,0.001906978,0.003574179,0.0003686357,0.001483812,0.0008096151,0.002140813,0.001730703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000842245,"about_ca_system_score_gemma":0.00186609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695794,"about_ca_topic_score_gemma":0.003058407,"domain_scores_codex":[0.9993728,0.0001568158,0.0001351084,0.00006894267,0.0002281982,0.00003825315],"domain_scores_gemma":[0.9989704,0.0006535818,0.0001752188,0.0000251475,0.0001436794,0.00003202836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001308472,0.00005799802,0.00009901112,0.148155,0.0004535578,0.0001499653,0.00007798899,0.0003392246,0.0006240591,0.002971355,0.0220227,0.8249182],"study_design_scores_gemma":[0.00007406886,0.0001665833,0.001067544,0.04909248,0.001225547,0.001075138,0.00007975118,0.00008607786,0.0002858948,0.002684621,0.9441363,0.00002589315],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003199833,0.9993402,0.0000372776,0.0001303126,0.00006802181,0.000005400341,0.00001325757,0.000003155965,0.000370404],"genre_scores_gemma":[0.0002735793,0.999292,0.00009840469,0.0001320775,0.00005040079,0.000005195619,0.00001824275,8.093167e-7,0.0001291655],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007195967,"threshold_uncertainty_score":0.02407295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08867855785025577,"score_gpt":0.4438249453203605,"score_spread":0.3551463874701047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}