{"id":"W4328025600","doi":"10.1055/s-0043-1761854","title":"MAPK and mTOR Inhibition Improves Childhood RASopathy-Associated Hypertrophic Cardiomyopathy","year":2023,"lang":"en","type":"article","venue":"The Thoracic and Cardiovascular Surgeon","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Université Laval; BC Children's Hospital","funders":"","keywords":"MAPK/ERK pathway; PI3K/AKT/mTOR pathway; Medicine; Protein kinase A; Kinase; Cancer research; Germline mutation; Mutation; Internal medicine; Signal transduction; Cell biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00251735,0.0003305717,0.0009927152,0.0001799586,0.0005092539,0.00006436097,0.00005913679,0.0001601028,0.000004744981],"category_scores_gemma":[0.0002477749,0.0002319047,0.0008703347,0.0006565118,0.0002692984,0.0001053908,0.000228256,0.0003103287,0.00003527688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003746771,"about_ca_system_score_gemma":0.00005037656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001100164,"about_ca_topic_score_gemma":0.000003720091,"domain_scores_codex":[0.9977372,0.0003492518,0.0002935094,0.000537008,0.0005876229,0.0004954197],"domain_scores_gemma":[0.9988542,0.0001401173,0.00006576835,0.0006414378,0.000132359,0.0001660944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0008808961,0.0002741818,0.05318141,0.0009523039,0.01542602,0.00235598,0.00751016,0.00006643371,0.01448715,0.0003700794,0.004714829,0.8997806],"study_design_scores_gemma":[0.002261248,0.0002823913,0.9712775,0.0003382428,0.004291906,0.001509229,0.003362233,0.000114183,0.002019279,0.0005659647,0.01336083,0.0006169846],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952813,0.04417624,0.00005835058,0.000513649,0.0003559433,0.0006258156,0.00003071678,0.0003393647,0.001086869],"genre_scores_gemma":[0.9856956,0.01314211,0.00001411802,0.0001827643,0.0004040756,0.00009919158,0.00006532954,0.00005318167,0.0003436465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9180961,"threshold_uncertainty_score":0.94568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01327452882540224,"score_gpt":0.2362742964463534,"score_spread":0.2229997676209511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}