{"id":"W4328048111","doi":"10.1097/j.pain.0000000000002888","title":"Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement","year":2023,"lang":"en","type":"article","venue":"Pain","topic":"Pain Management and Placebo Effect","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; Biotechnology and Biological Sciences Research Council; GW Research; School of Medicine, Indiana University; National Institute on Aging; Medical Center, University of Rochester; GlaxoSmithKline; University of California, San Francisco; Centers for Disease Control and Prevention; University of Texas MD Anderson Cancer Center; U.S. Food and Drug Administration; National Institutes of Health; Hamilton Health Sciences Foundation; H. Lundbeck A/S; National Institute of Dental and Craniofacial Research; Royal Society; Eikonizo Therapeutics; European Commission; Glenmark Pharmaceuticals; National Institute for Health and Care Research; Voyager Therapeutics; Teikoku Pharma USA; National Center for Complementary and Integrative Health; British Pain Society; North American Neuromodulation Society; U.S. Department of Veterans Affairs; George Washington University; GW Pharmaceuticals; ACADIA Pharmaceuticals; Royal British Legion; Kaiser Permanente Washington Health Research Institute; Boston Scientific Corporation; Astellas Pharma; Virginia Commonwealth University; Allergan; York University; University of Washington; Pfizer; Biogen; University of Rochester; Memorial Sloan-Kettering Cancer Center; Stowers Institute for Medical Research; Celgene; PTC Therapeutics; Neurocrine Biosciences; Weill Cornell Medical College; Hospital for Special Surgery; Imperial College London; Medical Research Council; Patient-Centered Outcomes Research Institute; Cure SMA; UK Research and Innovation; Versus Arthritis; Eli Lilly and Company; Teva Pharmaceutical Industries; University of Southern California","keywords":"Clinical trial; Context (archaeology); External validity; Internal validity; Systematic review; Health care; Medicine; Set (abstract data type); Psychology; MEDLINE; Management science; Computer science; Political science; Social psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3510767,0.0001024631,0.0003617362,0.0002413547,0.0002201605,0.00007009106,0.00007594298,0.00004369212,0.00006526166],"category_scores_gemma":[0.2879429,0.00007963991,0.0001153658,0.0003224574,0.0001467789,0.00008697501,0.00004874369,0.00009403787,0.00001842903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000302965,"about_ca_system_score_gemma":0.00006679229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002579133,"about_ca_topic_score_gemma":0.00001589056,"domain_scores_codex":[0.8750307,0.1227056,0.0009932189,0.0004550683,0.0003865686,0.000428828],"domain_scores_gemma":[0.750316,0.2492244,0.0001667967,0.0001805894,0.00004212294,0.00007011266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008713425,0.001074431,0.02531412,0.001123659,0.000569476,0.0000716172,0.004052886,0.0006835624,0.1867176,0.02778358,0.3853115,0.3664263],"study_design_scores_gemma":[0.006350785,0.002859844,0.01073149,0.000239769,0.0001714873,0.000001499414,0.002382836,0.8238814,0.02778432,0.1121947,0.01291002,0.0004918643],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7520469,0.0003645651,0.2103349,0.01229266,0.0007346151,0.01854744,0.0007637294,0.0004750662,0.004440175],"genre_scores_gemma":[0.9957166,0.0002525092,0.00125304,0.0003878339,0.0001010332,0.0005149253,0.00002446801,0.00001624303,0.001733301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8231978,"threshold_uncertainty_score":0.7180551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4445512382776505,"score_gpt":0.5481775622852708,"score_spread":0.1036263240076203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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