{"id":"W4328048111","doi":"10.1097/j.pain.0000000000002888","title":"Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement","year":2023,"lang":"en","type":"article","venue":"Pain","topic":"Pain Management and Placebo Effect","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; Biotechnology and Biological Sciences Research Council; GW Research; School of Medicine, Indiana University; National Institute on Aging; Medical Center, University of Rochester; GlaxoSmithKline; University of California, San Francisco; Centers for Disease Control and Prevention; University of Texas MD Anderson Cancer Center; U.S. Food and Drug Administration; National Institutes of Health; Hamilton Health Sciences Foundation; H. Lundbeck A/S; National Institute of Dental and Craniofacial Research; Royal Society; Eikonizo Therapeutics; European Commission; Glenmark Pharmaceuticals; National Institute for Health and Care Research; Voyager Therapeutics; Teikoku Pharma USA; National Center for Complementary and Integrative Health; British Pain Society; North American Neuromodulation Society; U.S. Department of Veterans Affairs; George Washington University; GW Pharmaceuticals; ACADIA Pharmaceuticals; Royal British Legion; Kaiser Permanente Washington Health Research Institute; Boston Scientific Corporation; Astellas Pharma; Virginia Commonwealth University; Allergan; York University; University of Washington; Pfizer; Biogen; University of Rochester; Memorial Sloan-Kettering Cancer Center; Stowers Institute for Medical Research; Celgene; PTC Therapeutics; Neurocrine Biosciences; Weill Cornell Medical College; Hospital for Special Surgery; Imperial College London; Medical Research Council; Patient-Centered Outcomes Research Institute; Cure SMA; UK Research and Innovation; Versus Arthritis; Eli Lilly and Company; Teva Pharmaceutical Industries; University of Southern California","keywords":"Clinical trial; Context (archaeology); External validity; Internal validity; Systematic review; Health care; Medicine; Set (abstract data type); Psychology; MEDLINE; Management science; Computer science; Political science; Social psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.770609,0.004507714,0.01064585,0.005694124,0.006170983,0.01880912,0.01028047,0.05821039,0.005795335],"category_scores_gemma":[0.8164584,0.005258919,0.009282785,0.006505043,0.03066994,0.02151275,0.01365797,0.05388857,0.004864907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01292548,"about_ca_system_score_gemma":0.05659303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001677419,"about_ca_topic_score_gemma":0.001923524,"domain_scores_codex":[0.1544419,0.688219,0.1092147,0.009559002,0.03598319,0.002582175],"domain_scores_gemma":[0.08142805,0.8182462,0.02358362,0.03000726,0.04265085,0.004084153],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002899074,0.0002746721,0.001092526,0.05175934,0.001937353,0.0008558119,0.007825889,0.003734683,0.0008104156,0.5849803,0.1835041,0.1603258],"study_design_scores_gemma":[0.003929211,0.001315472,0.001316499,0.09660127,0.001827004,0.001310511,0.00111921,0.007881003,0.001718357,0.5660532,0.3164026,0.0005256319],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.000970465,0.03134128,0.1900872,0.7117617,0.02736016,0.02582617,0.001502671,0.0004146342,0.01073587],"genre_scores_gemma":[0.01588452,0.006677522,0.5657939,0.2913412,0.01357093,0.1044306,0.0005236988,0.0001842649,0.001593511],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.229391,"threshold_uncertainty_score":0.2828799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4445512382776505,"score_gpt":0.5481775622852708,"score_spread":0.1036263240076203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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