{"id":"W4328048397","doi":"10.1038/s42255-023-00766-2","title":"PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing","year":2023,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Guelph","funders":"National Institutes of Health; Bundesministerium für Bildung, Wissenschaft und Forschung; Science for Life Laboratory; Karolinska Institutet; Université de Strasbourg; Österreichische Forschungsförderungsgesellschaft; Österreichischen Akademie der Wissenschaften; Agence Nationale de la Recherche; Austrian Science Fund; European Commission; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Spastic Paraplegia Foundation","keywords":"Failure to thrive; Muscle weakness; Ageing; Skeletal muscle; Biology; Muscular dystrophy; Sarcopenia; Cell biology; Internal medicine; Medicine; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002238362,0.0005311412,0.0003662939,0.0003201985,0.0004597275,0.0009879933,0.000232727,0.0007184271,0.003878822],"category_scores_gemma":[0.0002213041,0.000209016,0.0003968878,0.0002919209,0.0003558002,0.0004913856,0.0008416373,0.0007523732,0.001449762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005416274,"about_ca_system_score_gemma":0.0004279104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007083616,"about_ca_topic_score_gemma":0.001304408,"domain_scores_codex":[0.9998088,0.0000189672,0.00001388989,0.00007039297,0.00004226848,0.00004550316],"domain_scores_gemma":[0.9998528,0.000009643015,0.0000421636,0.00001463328,0.00003372435,0.0000470483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0022507,0.00004421897,0.001968077,0.0003265891,0.00006792283,0.0005468066,0.00004289047,0.0002719134,0.9774166,0.001852536,0.002952977,0.01225875],"study_design_scores_gemma":[0.0002446919,0.0005326261,0.04800479,0.0001450113,0.0001417219,0.002712716,0.0002512044,0.003973487,0.8599554,0.002241676,0.08174251,0.00005415328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9020638,0.04541994,0.01805398,0.004274511,0.001634728,0.0001580117,0.005557193,0.0009401152,0.02189768],"genre_scores_gemma":[0.9716827,0.005496943,0.003133071,0.0004765242,0.0001396527,0.00007294479,0.002608295,0.0001493651,0.01624036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003878822,"threshold_uncertainty_score":0.01297599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01443893291395624,"score_gpt":0.3356367837640801,"score_spread":0.3211978508501238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}