{"id":"W4328048397","doi":"10.1038/s42255-023-00766-2","title":"PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing","year":2023,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Guelph","funders":"National Institutes of Health; Bundesministerium für Bildung, Wissenschaft und Forschung; Science for Life Laboratory; Karolinska Institutet; Université de Strasbourg; Österreichische Forschungsförderungsgesellschaft; Österreichischen Akademie der Wissenschaften; Agence Nationale de la Recherche; Austrian Science Fund; European Commission; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Spastic Paraplegia Foundation","keywords":"Failure to thrive; Muscle weakness; Ageing; Skeletal muscle; Biology; Muscular dystrophy; Sarcopenia; Cell biology; Internal medicine; Medicine; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002542493,0.0001814065,0.0004282276,0.0002667622,0.0001502398,0.00003030694,0.00009243432,0.0002598125,0.0002426277],"category_scores_gemma":[0.0005164634,0.0001488762,0.0001020973,0.0007289147,0.00005971935,0.0000673149,0.0000607326,0.0004185382,0.000176573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002066785,"about_ca_system_score_gemma":0.0001073836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002391971,"about_ca_topic_score_gemma":0.000001835278,"domain_scores_codex":[0.9985758,0.00006709638,0.000213784,0.0003850286,0.0003350846,0.0004231843],"domain_scores_gemma":[0.998787,0.0001356955,0.00003127467,0.0003573657,0.00008120148,0.0006074638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008094332,0.0005418476,0.0007808187,0.0008261918,0.0006857812,0.001233954,0.007798311,0.000002699117,0.0887724,0.02628268,0.2344874,0.6377785],"study_design_scores_gemma":[0.001450335,0.0001347548,0.3621907,0.0002487573,0.0001802573,0.00002541316,0.0003768098,0.0002620152,0.01974315,0.001640956,0.6134088,0.0003380536],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9283563,0.02098135,0.0000322597,0.04848383,0.0006645492,0.0003846476,0.00006230999,0.0003932632,0.0006414818],"genre_scores_gemma":[0.9628994,0.0008875424,0.0006517349,0.03399104,0.0007656839,0.00001673289,0.00002450523,0.00004339183,0.0007199248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6374404,"threshold_uncertainty_score":0.6070997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01443893291395624,"score_gpt":0.3356367837640801,"score_spread":0.3211978508501238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}