{"id":"W4328051667","doi":"10.1523/jneurosci.1593-22.2023","title":"Axonal ER Ca<sup>2+</sup>Release Selectively Enhances Activity-Independent Glutamate Release in a Huntington Disease Model","year":2023,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Canadian Open Neuroscience Platform; Michael Smith Health Research BC; University of British Columbia; Government of Canada; Hereditary Disease Foundation","keywords":"Huntington's disease; Glutamate receptor; Chemistry; Neuroscience; Disease; Biology; Biochemistry; Internal medicine; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169347,0.000593752,0.000627898,0.0003564473,0.0001909952,0.0003934583,0.0003657771,0.0005144603,0.001346568],"category_scores_gemma":[0.0001292825,0.0002691726,0.0003370177,0.000211368,0.0002894336,0.0003047841,0.0003458351,0.0009423299,0.0004482714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002607467,"about_ca_system_score_gemma":0.0001745968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006313475,"about_ca_topic_score_gemma":0.001353628,"domain_scores_codex":[0.9998178,0.00001630909,0.00003208643,0.00003725013,0.00005541331,0.00004118721],"domain_scores_gemma":[0.9997329,0.0000367972,0.00008223373,0.0000380257,0.00002638698,0.00008368515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000134484,0.0000295917,0.00009500315,0.00002224078,0.000004701102,0.0000881115,0.00000859343,0.00002152862,0.9992774,0.00001540014,0.00002065317,0.000282327],"study_design_scores_gemma":[0.00004167219,0.000911828,0.008812538,0.00001151799,0.00004970485,0.0006188131,0.00005126651,0.0009466916,0.9875437,0.00004311744,0.0009602521,0.000008838098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979669,0.000297561,0.000647206,0.00005460022,0.00001724785,0.00002107527,0.0003715541,0.00005767147,0.0005661159],"genre_scores_gemma":[0.9928749,0.0005453597,0.001977848,0.00004954098,0.00001157175,0.000101384,0.000651208,0.00004809789,0.003740197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346568,"threshold_uncertainty_score":0.004504681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03712674183249787,"score_gpt":0.2917942449255743,"score_spread":0.2546675030930765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}