{"id":"W4328053564","doi":"10.1016/j.xkme.2023.100631","title":"Alport Syndrome: Clinical Spectrum and Therapeutic Advances","year":2023,"lang":"en","type":"review","venue":"Kidney Medicine","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Alport Syndrome Foundation","keywords":"Alport syndrome; Type IV collagen; X chromosome; Sensorineural hearing loss; Hearing loss; Medicine; Glomerular basement membrane; Glomerulonephritis; Genetics; Kidney; Internal medicine; Endocrinology; Biology; Pathology; Laminin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002049236,0.0006211285,0.00417998,0.0006527525,0.00008506754,0.00001429786,0.0003341975,0.0005480408,0.001661227],"category_scores_gemma":[0.002997024,0.0003871263,0.0004687562,0.001034035,0.0008154938,0.0000319961,0.0002522951,0.001682516,0.001116779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001143788,"about_ca_system_score_gemma":0.001277422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000203976,"about_ca_topic_score_gemma":0.00000344591,"domain_scores_codex":[0.9951754,0.0003640502,0.001622885,0.001032686,0.0011377,0.0006672791],"domain_scores_gemma":[0.9957232,0.001103466,0.0003803353,0.001014586,0.00008127281,0.001697115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003302972,0.00008308965,0.000127364,0.0365026,0.000531866,0.003065472,0.00001774461,4.224645e-9,8.067448e-7,0.00007018417,0.03543591,0.9241319],"study_design_scores_gemma":[0.001241539,0.001205881,0.0002097412,0.03920335,0.002165215,0.002684148,0.0000240269,0.000005826662,3.615159e-7,0.0001757436,0.9527909,0.0002932665],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000009727695,0.9876459,0.00001432331,0.004785767,0.0008767147,0.00173803,0.00002456149,0.0002100793,0.004694862],"genre_scores_gemma":[0.000008155218,0.9776787,0.00007023628,0.001561451,0.001132258,0.0001049041,0.0003392398,0.0001945586,0.01891052],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9238387,"threshold_uncertainty_score":0.9998581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1713332410544479,"score_gpt":0.4888971733972399,"score_spread":0.317563932342792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}