{"id":"W4328053735","doi":"10.46747/cfp.6903160","title":"Challenges with new treatments for Alzheimer disease","year":2023,"lang":"en","type":"article","venue":"Canadian Family Physician","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Disease; Alzheimer's disease; Medicine; Bioinformatics; Gerontology; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000328326,0.0002408312,0.0002600569,0.000254617,0.0001761075,0.00002662856,0.0000981287,0.00004495935,0.000005202708],"category_scores_gemma":[0.000006428128,0.0001926784,0.0001399749,0.0003299183,0.00006483681,0.0001020921,0.00001206814,0.00006919698,0.0006899144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840003,"about_ca_system_score_gemma":0.002214975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003936058,"about_ca_topic_score_gemma":0.003835092,"domain_scores_codex":[0.9983929,0.00001415788,0.0001054955,0.0004251769,0.0002734203,0.0007888106],"domain_scores_gemma":[0.9964427,0.00003702384,0.00002825949,0.0004360434,0.00008459193,0.002971417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002667098,0.0009928453,0.01233186,0.0002077046,0.05593641,0.004174697,0.0003647502,0.0000294715,0.0001022479,0.00349735,0.2559054,0.6637901],"study_design_scores_gemma":[0.009163323,0.001530167,0.8950241,0.0003459215,0.006228454,0.000002574282,0.0008304204,0.0002364349,0.00019813,0.002451729,0.08331674,0.0006719787],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4025772,0.1904292,0.00002993994,0.03698928,0.0006423923,0.01328203,0.003698718,0.001351489,0.3509998],"genre_scores_gemma":[0.9823284,0.0008817562,0.0001275533,0.01295755,0.000592149,0.0005185085,0.001349649,0.0001386255,0.001105766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8826923,"threshold_uncertainty_score":0.8867684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08876730030563162,"score_gpt":0.319323587938197,"score_spread":0.2305562876325654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}