{"id":"W4328053757","doi":"10.3928/23258160-20230221-04","title":"Safety and Efficacy of a Treat-and-Extend Regimen of Anti–Vascular Endothelial Growth Factor Agents for Diabetic Macular Edema or Macular Edema Secondary to Retinal Vein Occlusion: A Systematic Review and Meta-Analysis","year":2023,"lang":"en","type":"review","venue":"Ophthalmic surgery, lasers & imaging retina","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Macular edema; Regimen; Retinal Vein; Visual acuity; Branch retinal vein occlusion; Ranibizumab; Edema; Ophthalmology; Occlusion; Central retinal vein occlusion; Retinal; Surgery; Bevacizumab; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01132758,0.002092128,0.01340614,0.003712581,0.0005954031,0.00296519,0.001476941,0.002102213,0.002955172],"category_scores_gemma":[0.02526437,0.001373854,0.03936536,0.003856941,0.0006263357,0.001584545,0.0009914638,0.001940492,0.0002867641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002223382,"about_ca_system_score_gemma":0.002169919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00555728,"about_ca_topic_score_gemma":0.01200603,"domain_scores_codex":[0.9926348,0.003761441,0.001908257,0.0007579673,0.0006947603,0.0002428181],"domain_scores_gemma":[0.9859121,0.009940792,0.002375704,0.0004904185,0.001086346,0.0001946057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005430674,0.00005545881,0.004574094,0.1719722,0.8088812,0.00009336936,0.00006056702,0.0004233348,0.0002509188,0.00008428995,0.0003541236,0.007819834],"study_design_scores_gemma":[0.001049464,0.000333722,0.003105313,0.008269687,0.9862687,0.00005947804,0.00002881461,0.000154435,0.0001015916,0.00008326022,0.0005297985,0.00001569716],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02066395,0.9768327,0.0005944969,0.0002492132,0.0001876802,0.0004407151,0.0005774555,0.00002830496,0.000425364],"genre_scores_gemma":[0.4721498,0.521247,0.002338562,0.001063317,0.0003478774,0.001328004,0.0009660342,0.00003146651,0.0005278383],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01340614,"threshold_uncertainty_score":0.05990666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05668392714092827,"score_gpt":0.3467357675115036,"score_spread":0.2900518403705754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}