{"id":"W4328053950","doi":"10.1016/j.jcmgh.2023.02.015","title":"PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation","year":2023,"lang":"en","type":"letter","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Universidad de Navarra; Instituto de Salud Carlos III; Ikerbasque, Basque Foundation for Science; Medical Research Council; Euskal Herriko Unibertsitatea; European Regional Development Fund; PSC Partners Seeking a Cure; Eusko Jaurlaritza; European Commission","keywords":"Hepatocellular carcinoma; Cancer research; Cancer; Scopus; Reprogramming; Medicine; Cancer cell; Tumor progression; Internal medicine; Bioinformatics; Oncology; Cell; Biology; MEDLINE; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001535713,0.0004818205,0.0009097653,0.0001332683,0.000117585,0.00002159138,0.0001814286,0.00118562,0.0000116673],"category_scores_gemma":[0.00003296386,0.000477209,0.0001754931,0.0000754023,0.000908589,0.00001010812,0.0003130199,0.0005669034,0.000002214664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005682095,"about_ca_system_score_gemma":0.00006107826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003389629,"about_ca_topic_score_gemma":0.00004248602,"domain_scores_codex":[0.9975544,0.0002498738,0.0004475335,0.0009869611,0.0001698966,0.0005912931],"domain_scores_gemma":[0.9989935,0.00001855066,0.0003225219,0.0004532852,0.0001088918,0.0001032978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007700843,0.00008820395,0.02152311,0.001013659,0.0009769134,0.0002861257,0.0004523661,8.723906e-7,0.6505019,0.0003074224,0.3220458,0.002033508],"study_design_scores_gemma":[0.002477901,0.0007657539,0.002446608,0.0001020281,0.0006929947,0.000444293,0.00004605818,0.00004843106,0.1659955,0.0006249726,0.8258498,0.0005055863],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9291432,0.03219839,0.001713104,0.03534757,0.0008416683,0.0005008293,0.0001590863,0.00002796087,0.00006814735],"genre_scores_gemma":[0.6776016,0.05241189,0.002710532,0.260031,0.00308205,0.0002933627,0.002443998,0.0002657098,0.001159778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.503804,"threshold_uncertainty_score":0.999768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007194938132076311,"score_gpt":0.2366898840556151,"score_spread":0.2294949459235388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}