{"id":"W4328053950","doi":"10.1016/j.jcmgh.2023.02.015","title":"PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation","year":2023,"lang":"en","type":"letter","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Universidad de Navarra; Instituto de Salud Carlos III; Ikerbasque, Basque Foundation for Science; Medical Research Council; Euskal Herriko Unibertsitatea; European Regional Development Fund; PSC Partners Seeking a Cure; Eusko Jaurlaritza; European Commission","keywords":"Hepatocellular carcinoma; Cancer research; Cancer; Scopus; Reprogramming; Medicine; Cancer cell; Tumor progression; Internal medicine; Bioinformatics; Oncology; Cell; Biology; MEDLINE; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003317008,0.0002948115,0.0004256514,0.0006338463,0.0005187728,0.0008904019,0.0003336851,0.0005321208,0.009580813],"category_scores_gemma":[0.000460679,0.0002028289,0.0004879099,0.0005697037,0.0003171427,0.0005577203,0.0005284413,0.0009036225,0.00164047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007184487,"about_ca_system_score_gemma":0.0005313653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312443,"about_ca_topic_score_gemma":0.0009878846,"domain_scores_codex":[0.9997984,0.00002937835,0.00001120942,0.00003621437,0.00006405143,0.00006088409],"domain_scores_gemma":[0.9997978,0.00002449927,0.00006166198,0.00001902637,0.00003918951,0.0000579132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005416989,0.0004235903,0.05138856,0.002204256,0.0005091911,0.00278935,0.0003383754,0.001992404,0.7371231,0.007898874,0.02992594,0.1599895],"study_design_scores_gemma":[0.0005042104,0.001229763,0.3332753,0.0004827635,0.0006891121,0.01245491,0.001125045,0.009111914,0.4489374,0.01040347,0.1816004,0.0001858552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9048475,0.04671264,0.007307714,0.009633028,0.0006454382,0.00009044918,0.005830932,0.0009425642,0.02398971],"genre_scores_gemma":[0.9836701,0.00593133,0.001049294,0.0003800983,0.0000732457,0.00003374649,0.002601536,0.00005753959,0.006203118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009580813,"threshold_uncertainty_score":0.03205103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007194938132076311,"score_gpt":0.2366898840556151,"score_spread":0.2294949459235388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}