{"id":"W4328089032","doi":"10.1016/j.cmet.2023.03.008","title":"Epigenetic dosage identifies two major and functionally distinct β cell subtypes","year":2023,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; University of Alberta; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; H2020 European Research Council; European Foundation for the Study of Diabetes; National Cancer Institute; European Research Council; National Institutes of Health","keywords":"Epigenetics; Biology; Histone; Epigenesis; Computational biology; Cell; Cell type; Cell biology; Genetics; DNA methylation; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000232836,0.0001933186,0.0002760863,0.0003621042,0.0001571338,0.0006722459,0.000285421,0.0002193851,0.00132521],"category_scores_gemma":[0.0003861891,0.0002160403,0.0002086898,0.000182335,0.000296969,0.0003552474,0.0004250851,0.0003530172,0.0003210862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000226086,"about_ca_system_score_gemma":0.0001269693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003547225,"about_ca_topic_score_gemma":0.0005543354,"domain_scores_codex":[0.9998382,0.00001904584,0.00001454511,0.00006072212,0.00004217731,0.00002526352],"domain_scores_gemma":[0.9996898,0.00006072121,0.0001039279,0.00005480836,0.00004326359,0.00004745549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510633,0.000007629102,0.01146135,0.00002819898,0.00001961451,0.00005513926,0.00006980114,0.00004735831,0.979126,0.0005841391,0.00005076766,0.008399006],"study_design_scores_gemma":[0.00002863038,0.0003969497,0.3686322,0.00003178108,0.0001271315,0.001475016,0.000325115,0.001514244,0.6179913,0.001246628,0.008200744,0.00003024588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871497,0.0019955,0.008021658,0.0001290622,0.00001995515,0.0000141257,0.0003362393,0.00008984635,0.002243926],"genre_scores_gemma":[0.9950251,0.0008057047,0.002064613,0.00008079672,0.00001750332,0.00001386883,0.0003292423,0.00003556109,0.001627522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132521,"threshold_uncertainty_score":0.004433274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223580645140325,"score_gpt":0.2416581308198511,"score_spread":0.2294223243684479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}