{"id":"W4328127360","doi":"10.1021/acscentsci.3c00054","title":"SARS-CoV-2 M<sup>pro</sup> Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals","year":2023,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Narodowe Centrum Nauki; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Office of Science; National Institutes of Health; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Energy; Fundacja na rzecz Nauki Polskiej; Government of Alberta; Canada Foundation for Innovation; Alberta Innovates","keywords":"Protease; Mutant; Proteolysis; Viral replication; Biology; Mutation; Virology; Virulence; Peptide; Virus; Chemistry; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000950397,0.0002158201,0.0001559785,0.0001122884,0.00007058695,0.0002271042,0.000149076,0.0002736426,0.001472451],"category_scores_gemma":[0.00009570131,0.0001084372,0.0001787143,0.0001112826,0.0001325912,0.0001647646,0.00009898798,0.0003684795,0.0003459677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598813,"about_ca_system_score_gemma":0.0000667605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004785583,"about_ca_topic_score_gemma":0.00049647,"domain_scores_codex":[0.9998934,0.00001611087,0.00001174895,0.00002381646,0.00003010493,0.00002462394],"domain_scores_gemma":[0.9999299,0.00001647706,0.00002138178,0.00001057352,0.000008671974,0.00001304156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000981857,0.00001123374,0.000187396,0.000007441663,0.000002758343,0.00003862659,0.00000634645,0.00003436386,0.9991937,0.00002788712,0.00002517016,0.0003668687],"study_design_scores_gemma":[0.000007765099,0.0001983153,0.007374682,0.000001503382,0.00000618418,0.0004832158,0.00002272115,0.0007433213,0.9901307,0.00002411181,0.001002953,0.000004558945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971916,0.0002205042,0.001175391,0.00004469082,0.000008443282,0.000007359777,0.0004479736,0.00004783929,0.0008563112],"genre_scores_gemma":[0.9936717,0.0001902118,0.002443532,0.00005797925,0.000004291222,0.00001235699,0.001254242,0.00004010005,0.0023256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472451,"threshold_uncertainty_score":0.004925787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862981738265897,"score_gpt":0.2657739388988898,"score_spread":0.2371441215162308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}