{"id":"W4328127360","doi":"10.1021/acscentsci.3c00054","title":"SARS-CoV-2 M<sup>pro</sup> Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals","year":2023,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Narodowe Centrum Nauki; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Office of Science; National Institutes of Health; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Energy; Fundacja na rzecz Nauki Polskiej; Government of Alberta; Canada Foundation for Innovation; Alberta Innovates","keywords":"Protease; Mutant; Proteolysis; Viral replication; Biology; Mutation; Virology; Virulence; Peptide; Virus; Chemistry; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001231802,0.0002871215,0.000406223,0.0001450119,0.0005480145,0.0001108709,0.0003644137,0.0001844445,0.00002154201],"category_scores_gemma":[0.000228123,0.0002484488,0.00006704868,0.0007349568,0.001234311,0.0006925506,0.0002600125,0.000350965,0.00006754406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005619665,"about_ca_system_score_gemma":0.0003717511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003490129,"about_ca_topic_score_gemma":0.000009460299,"domain_scores_codex":[0.9972976,0.0002570982,0.0004021871,0.0007194376,0.0001604894,0.00116317],"domain_scores_gemma":[0.9991705,0.00007671703,0.000261336,0.0003052818,0.0001241067,0.00006209296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114001,0.00009401172,0.003446066,0.00006917506,0.00001588428,0.00003415115,0.001601761,0.00001475032,0.9930863,0.0002135019,0.0001048422,0.001208199],"study_design_scores_gemma":[0.0008184183,0.0001996184,0.04907862,0.00008131829,0.000020736,0.00004709469,0.0004955899,0.001583098,0.9470733,0.00019874,0.0001136096,0.0002898872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975658,0.0002892883,0.000533001,0.0001377892,0.0003204259,0.0006560266,0.0001773409,0.0001055468,0.000214786],"genre_scores_gemma":[0.9990898,0.00006334607,0.0002985728,0.00009949498,0.00003254295,0.00001431734,0.00003023187,0.00001961577,0.0003520118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04601299,"threshold_uncertainty_score":0.9999968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862981738265897,"score_gpt":0.2657739388988898,"score_spread":0.2371441215162308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}