{"id":"W4353014874","doi":"10.1099/jgv.0.001833","title":"Seneca Valley virus enters cells through multiple pathways and traffics intracellularly via the endolysosomal pathway","year":2023,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Dynamin; Biology; Endosome; Endocytosis; Cell biology; Small interfering RNA; Clathrin; Viral entry; Gene knockdown; Nocodazole; RNA interference; Pinocytosis; Internalization; LAMP1; HEK 293 cells; Virology; Virus; Viral replication; RNA; Biochemistry; Intracellular; Apoptosis; Receptor; Cytoskeleton; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008229126,0.0002460001,0.0003212621,0.0001102291,0.0001878151,0.00004459396,0.0004767623,0.0002630469,0.00003406473],"category_scores_gemma":[0.00007058782,0.0001771448,0.0002264416,0.0001782932,0.0002725913,0.00001451725,0.0001966789,0.0004307078,0.00002172802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002210683,"about_ca_system_score_gemma":0.0001377306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000205513,"about_ca_topic_score_gemma":0.000152046,"domain_scores_codex":[0.9978646,0.0004678727,0.0005019842,0.0003171144,0.0003136763,0.0005347742],"domain_scores_gemma":[0.9989831,0.00009899145,0.0002705883,0.0003610546,0.0001344991,0.000151793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001822453,0.0000874555,0.0002838745,0.000008376094,0.0001895698,0.0001338443,0.0002727851,0.002652749,0.9873265,0.00002465353,0.001753528,0.005444215],"study_design_scores_gemma":[0.001891621,0.005250575,0.0008643115,0.000005008439,0.00003097481,0.0003431993,0.0001161848,0.001858262,0.9701254,0.0001874937,0.01911685,0.0002100604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948246,0.00211376,0.001179275,0.001084227,0.0005144071,0.0001852217,0.00003122197,0.00001453742,0.000052693],"genre_scores_gemma":[0.9944625,0.002958418,0.0003883041,0.0009264551,0.0009483508,0.00001044748,0.00002602625,0.00004776903,0.0002317457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01736332,"threshold_uncertainty_score":0.7223754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122107741311307,"score_gpt":0.2566877682432623,"score_spread":0.2354666908301493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}