{"id":"W4353014874","doi":"10.1099/jgv.0.001833","title":"Seneca Valley virus enters cells through multiple pathways and traffics intracellularly via the endolysosomal pathway","year":2023,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Dynamin; Biology; Endosome; Endocytosis; Cell biology; Small interfering RNA; Clathrin; Viral entry; Gene knockdown; Nocodazole; RNA interference; Pinocytosis; Internalization; LAMP1; HEK 293 cells; Virology; Virus; Viral replication; RNA; Biochemistry; Intracellular; Apoptosis; Receptor; Cytoskeleton; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009997092,0.0003371307,0.0003935838,0.0002748362,0.000251702,0.0006491195,0.0001254726,0.0003110298,0.0007241509],"category_scores_gemma":[0.00007180245,0.0001430132,0.0004620994,0.0002047541,0.000171703,0.0003588911,0.000367497,0.0003978177,0.0004526014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00033314,"about_ca_system_score_gemma":0.0002853394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006480814,"about_ca_topic_score_gemma":0.001036622,"domain_scores_codex":[0.9998865,0.00001332995,0.00001110876,0.0000244535,0.00004071117,0.00002381584],"domain_scores_gemma":[0.9999363,0.000008428971,0.00001609482,0.000006771299,0.00001695349,0.0000154406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084194,0.00001238162,0.001053071,0.0001013564,0.00001739667,0.0001566165,0.00002886739,0.00006644373,0.9939349,0.0002863369,0.00006745288,0.004166644],"study_design_scores_gemma":[0.00002608554,0.0003715995,0.02060657,0.00005051171,0.00006189827,0.001686239,0.0001647648,0.002111907,0.9602513,0.0003127793,0.01432734,0.0000288709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756335,0.01094038,0.008730808,0.0001444353,0.00004057878,0.00005212496,0.000505278,0.0001634608,0.003789428],"genre_scores_gemma":[0.980099,0.007940452,0.005547157,0.00007611333,0.00001348537,0.00004414291,0.0007534107,0.00002319387,0.005502992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007241509,"threshold_uncertainty_score":0.002422452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122107741311307,"score_gpt":0.2566877682432623,"score_spread":0.2354666908301493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}