{"id":"W4353016822","doi":"10.1128/spectrum.04154-22","title":"Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada","funders":"Medical Research Council; U.S. Food and Drug Administration; Public Health England; Hamilton Health Sciences Foundation; National Institute for Health Research Health Protection Research Unit; National Institute for Health and Care Research; University of Oxford","keywords":"Ebola virus; Virology; Phenotype; Biology; Virus; Disease; Polymerase; Ebolavirus; Immunology; Medicine; Genetics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001494946,0.0004129229,0.0002481442,0.0006132579,0.000204455,0.0003069197,0.0001443274,0.000504093,0.002577935],"category_scores_gemma":[0.0004018969,0.000163213,0.0003353791,0.0002656385,0.0004090809,0.000123664,0.000375132,0.0005538772,0.000385373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001673292,"about_ca_system_score_gemma":0.0001177026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006068714,"about_ca_topic_score_gemma":0.0006466312,"domain_scores_codex":[0.9997488,0.00004636112,0.00003107763,0.00008495452,0.00004253054,0.00004624993],"domain_scores_gemma":[0.9996687,0.00006184594,0.0001542978,0.00003521027,0.00002260929,0.00005721091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004508654,0.00009307128,0.01315917,0.00003939075,0.00004922956,0.001273638,0.0001348298,0.0001358904,0.9815862,0.0002665201,0.0001261362,0.002685016],"study_design_scores_gemma":[0.0000643028,0.001133541,0.6569363,0.00008140397,0.0001931224,0.02745085,0.0007096688,0.002542914,0.3024279,0.001030829,0.007361987,0.00006718579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963882,0.0004384337,0.001702374,0.00005305602,0.00002735229,0.00001841297,0.0003727778,0.00003625799,0.0009631993],"genre_scores_gemma":[0.9979844,0.0001952732,0.0006125486,0.00004984701,0.000008892468,0.00001151504,0.0002255659,0.00003546243,0.000876467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002577935,"threshold_uncertainty_score":0.008624017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0245922899571735,"score_gpt":0.2823588333623586,"score_spread":0.2577665434051851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}