{"id":"W4353029215","doi":"10.1101/2023.03.21.23287487","title":"TEMPORAL TRENDS AND TRANSMISSION DYNAMICS OF PRE-TREATMENT HIV-1 DRUG RESISTANCE WITHIN AND BETWEEN RISK GROUPS IN KENYA, 1986-2020","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Alliance for Accelerating Excellence in Science in Africa; New Partnership for Africa's Development; Government of the United Kingdom; Svenska Sällskapet för Medicinsk Forskning; Wellcome Trust; African Academy of Sciences; Manitoba Health Research Council; Vetenskapsrådet; International AIDS Vaccine Initiative","keywords":"HIV drug resistance; Drug resistance; Transmission (telecommunications); Medicine; Demography; Human immunodeficiency virus (HIV); Antiretroviral therapy; Phylogenetic tree; Virology; Viral load; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006400333,0.0002716087,0.0001920967,0.001258991,0.0003918133,0.0005518424,0.0003488069,0.0004574766,0.001454564],"category_scores_gemma":[0.001444555,0.0002295711,0.000247577,0.001764319,0.0003095613,0.000531303,0.0004195813,0.0003727388,0.0002624199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001100341,"about_ca_system_score_gemma":0.000810587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.08605238,"about_ca_topic_score_gemma":0.100257,"domain_scores_codex":[0.9996118,0.00008309784,0.00004514338,0.00008237619,0.00005794203,0.0001197154],"domain_scores_gemma":[0.9992124,0.00007794841,0.0004404024,0.0000211678,0.0001467095,0.0001013089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001385936,0.00002101211,0.9952271,0.00007606417,0.00003475265,0.00008114227,0.000343241,0.000195131,0.0004305724,0.00005509274,0.0002632115,0.003134148],"study_design_scores_gemma":[0.000002163917,0.00002469477,0.9991993,0.00002013511,0.00001004536,0.00007538769,0.000221566,0.0001102489,0.00006209566,0.000004300116,0.0002681836,0.000001944698],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941826,0.001569891,0.0001005465,0.0001153677,0.000005575249,0.00002078699,0.003220965,0.000005433627,0.0007787577],"genre_scores_gemma":[0.9967675,0.0008993598,0.0001812111,0.00002669301,0.000007639997,0.00001296785,0.001826162,0.000001460499,0.0002769487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08605238,"threshold_uncertainty_score":0.171103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204867951714391,"score_gpt":0.3175449684717419,"score_spread":0.295496288954598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}