{"id":"W4353029365","doi":"10.1101/2023.03.22.23287578","title":"Patient-specific multi-modal modeling uncovers neurotransmitter receptor involvement in motor and non-motor axes of Parkinson’s disease","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Avid Radiopharmaceuticals; Horizon 2020 Framework Programme; Health Canada; Genentech; Weston Brain Institute; European Commission; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; McGill University; GlaxoSmithKline; Celgene; Biogen; Bristol-Myers Squibb; Allergan; Canada First Research Excellence Fund; Denali Therapeutics; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuroscience; Neurodegeneration; Neurotransmitter receptor; Neuroimaging; Psychology; Parkinson's disease; Dopaminergic; Neuropathology; Biology; Disease; Medicine; Receptor; Dopamine; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000383556,0.0003901381,0.0002781508,0.0003180293,0.0001123377,0.0005141175,0.0003601951,0.0005378005,0.001266745],"category_scores_gemma":[0.0006212735,0.0002150943,0.0007105884,0.0001742774,0.0002604555,0.0002205264,0.0003610716,0.0003721407,0.0001726911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003182039,"about_ca_system_score_gemma":0.000354583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003324746,"about_ca_topic_score_gemma":0.00321237,"domain_scores_codex":[0.9999297,0.00002813999,0.000003046768,0.00001829714,0.00001030174,0.0000105699],"domain_scores_gemma":[0.999871,0.00006365294,0.00002376315,0.00001794315,0.000009632253,0.00001396097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004535574,0.0001210435,0.02946979,0.0001182587,0.0004402616,0.0007936753,0.000220128,0.8908049,0.04079851,0.009251304,0.0021406,0.02538795],"study_design_scores_gemma":[0.0000154829,0.00003650074,0.005831278,0.000006004245,0.00003338385,0.000246819,0.00002992567,0.9849753,0.002342157,0.005967519,0.000503356,0.00001214251],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8187511,0.0002997432,0.1763879,0.0006296564,0.00002734251,0.00002877715,0.001260308,0.0007160617,0.001899083],"genre_scores_gemma":[0.9921823,0.00007075175,0.006800811,0.00003674594,0.000006169368,0.00001287701,0.0002882095,0.00004887295,0.0005531995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003324746,"threshold_uncertainty_score":0.006610811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04801440951348892,"score_gpt":0.2705631662388319,"score_spread":0.2225487567253429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}