{"id":"W4353033322","doi":"10.34133/bmef.0016","title":"Principles of Nanoparticle Delivery to Solid Tumors","year":2023,"lang":"en","type":"review","venue":"BME Frontiers","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Nanoparticle; Nanotechnology; Drug delivery; Cancer; Nanomedicine; In vivo; Materials science; Chemistry; Computer science; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006327707,0.0009042956,0.000884257,0.001845279,0.0005530089,0.001157151,0.000956859,0.001418523,0.002229046],"category_scores_gemma":[0.0003721639,0.0004129028,0.0004797287,0.0009385939,0.001405884,0.001276765,0.001059725,0.002413307,0.002835316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008304031,"about_ca_system_score_gemma":0.0008890422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005849258,"about_ca_topic_score_gemma":0.0006166494,"domain_scores_codex":[0.9996191,0.00005829558,0.00002857158,0.0000588028,0.000204829,0.00003028271],"domain_scores_gemma":[0.999916,0.00003264064,0.00001251072,0.000005904504,0.0000256851,0.000007331418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006027959,0.0001896929,0.0001266788,0.01638864,0.00007368079,0.0005712668,0.0003481232,0.002474273,0.04618512,0.1569971,0.02880691,0.7477782],"study_design_scores_gemma":[0.00001012001,0.00008601983,0.0001674048,0.0009309279,0.00001421164,0.0008224269,0.00002845935,0.0003628846,0.009220452,0.01196636,0.9763699,0.00002077881],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001157578,0.9526432,0.01717599,0.001854251,0.001041492,0.0001204807,0.00008843067,0.0001261148,0.02579247],"genre_scores_gemma":[0.01018952,0.9684616,0.00844461,0.0009948426,0.000445471,0.0002983808,0.00007227492,0.00002264941,0.01107066],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002229046,"threshold_uncertainty_score":0.007456839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06142127701766482,"score_gpt":0.3082033263539247,"score_spread":0.2467820493362599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}