{"id":"W4353060534","doi":"10.3390/ddc2010012","title":"Optimizing Protein Production in Therapeutic Phages against a Bacterial Pathogen, Mycobacterium abscessus","year":2023,"lang":"en","type":"article","venue":"Drugs and Drug Candidates","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Translation (biology); Gene; Genetics; Codon usage bias; Bacteriophage; Start codon; Stop codon; Phage therapy; Genome; Computational biology; Messenger RNA; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006002305,0.0004695544,0.0004181297,0.0003099003,0.0003602471,0.0005365435,0.0001774667,0.0003609271,0.0004361836],"category_scores_gemma":[0.0006284955,0.0002982646,0.0003465711,0.0003472587,0.0003505978,0.0002781147,0.0002608795,0.0004469137,0.000295221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000462842,"about_ca_system_score_gemma":0.0004589661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003192578,"about_ca_topic_score_gemma":0.000581485,"domain_scores_codex":[0.9995884,0.0001074832,0.00004827436,0.00006266835,0.0001351034,0.0000580083],"domain_scores_gemma":[0.9997256,0.00009667961,0.00007720322,0.0000249979,0.00004184804,0.00003365867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007233078,0.00004941953,0.000343849,0.00006973372,0.000003410672,0.00004223752,0.00003772551,0.001325552,0.9953845,0.000249875,0.00002858882,0.002392685],"study_design_scores_gemma":[0.00001071221,0.000322022,0.000642126,0.000007540096,0.00001170093,0.00006638617,0.00002707737,0.001656122,0.9960939,0.00009374834,0.001062371,0.000006252575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742612,0.000984853,0.02211342,0.000120052,0.00002690853,0.0001703798,0.000137974,0.0001046094,0.002080702],"genre_scores_gemma":[0.9304361,0.001341,0.06548957,0.00006197483,0.00001331128,0.0001807666,0.000258482,0.00009902757,0.002119881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006002305,"threshold_uncertainty_score":0.003358185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007070976741720812,"score_gpt":0.2256209737134503,"score_spread":0.2185499969717295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}