{"id":"W4353060830","doi":"10.1016/j.chembiol.2023.03.003","title":"Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120","year":2023,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Institute of Infection and Immunity; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Canada Foundation for Innovation; ViiV Healthcare","keywords":"Antibody-dependent cell-mediated cytotoxicity; Antigenicity; Glycoprotein; Bystander effect; Immune system; Gp41; Cell biology; Downregulation and upregulation; Antibody; Cytokine; Viral envelope; Chemistry; Biology; Immunology; Epitope; Biochemistry; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009947501,0.0001658217,0.0001885062,0.0001048419,0.0001024253,0.0001973227,0.0001639913,0.0001928248,0.001258452],"category_scores_gemma":[0.0001194837,0.00008200413,0.0001042601,0.00004105498,0.0001831756,0.0001166318,0.00008536791,0.0004474873,0.0001623195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000102661,"about_ca_system_score_gemma":0.0001426395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001396981,"about_ca_topic_score_gemma":0.0003157155,"domain_scores_codex":[0.9999436,0.00001836388,0.000004589928,0.000005837635,0.00001104162,0.0000164277],"domain_scores_gemma":[0.9999516,0.00001495437,0.000009228897,0.000007786549,0.000005758127,0.0000107053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000770602,0.0003038095,0.0004006697,0.00007841113,0.0000146785,0.00006698957,0.00002102877,0.0001743041,0.9793096,0.0004521786,0.0001400352,0.01826763],"study_design_scores_gemma":[0.0001010506,0.004281206,0.004105884,0.00001016361,0.00002329041,0.0006860056,0.00001848909,0.001468755,0.9849363,0.0001144997,0.004248981,0.000005367744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956878,0.001464829,0.000827398,0.00005435507,0.00002769062,0.00001840381,0.00005056931,0.00004701003,0.001821936],"genre_scores_gemma":[0.9971414,0.0007136537,0.0008538169,0.0000249852,0.00001771949,0.000009952691,0.00006948964,0.000004696542,0.001164332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258452,"threshold_uncertainty_score":0.004209995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505421965523603,"score_gpt":0.2489443699748534,"score_spread":0.2338901503196174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}