{"id":"W4353074900","doi":"10.3390/pharmaceutics15031009","title":"DLin-MC3-Containing mRNA Lipid Nanoparticles Induce an Antibody Th2-Biased Immune Response Polarization in a Delivery Route-Dependent Manner in Mice","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"Agence Nationale de la Recherche; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Sidaction","keywords":"Immunogenicity; Adjuvant; Immune system; Immunization; Avidity; Antibody; Antigen; Immunity; Immunology; Humoral immunity; Vaccine efficacy; Immunogen; Messenger RNA; Biology; Chemistry; Virology; Biochemistry; Gene; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003117578,0.0006114286,0.0004085129,0.0004352819,0.0001658453,0.0003398184,0.0002533614,0.0005642763,0.0009277429],"category_scores_gemma":[0.0001411812,0.0002757354,0.0003458582,0.0001606873,0.000449753,0.0003033292,0.0001691572,0.00113554,0.0003858896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003759891,"about_ca_system_score_gemma":0.0002604676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005093671,"about_ca_topic_score_gemma":0.0006998212,"domain_scores_codex":[0.999651,0.00004667136,0.00002891723,0.00009338942,0.00007721586,0.0001028289],"domain_scores_gemma":[0.9998296,0.00002908166,0.00006632663,0.00001906487,0.00002208613,0.0000339051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001473246,0.00004732041,0.00003843657,0.00002781359,0.00000331971,0.00001292986,0.00001290871,0.00005442963,0.9989485,0.00005072437,0.00002196534,0.0006342796],"study_design_scores_gemma":[0.00003319983,0.0005810825,0.0004691431,0.000004416136,0.00001303562,0.00004007182,0.00001023417,0.0005099564,0.9975032,0.00003031751,0.00080191,0.000003439061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986989,0.001282497,0.008011053,0.0002963216,0.0001024634,0.0001569084,0.0004701963,0.0002971814,0.00239434],"genre_scores_gemma":[0.9859929,0.0009763432,0.00650758,0.0002175218,0.00004044801,0.0002584436,0.0004510019,0.00009495067,0.00546076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009277429,"threshold_uncertainty_score":0.003103614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04153688482909806,"score_gpt":0.3452618183323994,"score_spread":0.3037249335033013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}