{"id":"W4353074900","doi":"10.3390/pharmaceutics15031009","title":"DLin-MC3-Containing mRNA Lipid Nanoparticles Induce an Antibody Th2-Biased Immune Response Polarization in a Delivery Route-Dependent Manner in Mice","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"Agence Nationale de la Recherche; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Sidaction","keywords":"Immunogenicity; Adjuvant; Immune system; Immunization; Avidity; Antibody; Antigen; Immunity; Immunology; Humoral immunity; Vaccine efficacy; Immunogen; Messenger RNA; Biology; Chemistry; Virology; Biochemistry; Gene; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009402559,0.0002068585,0.0001939178,0.0002522043,0.00006997183,0.00005407884,0.0002968607,0.0001800967,0.0000132437],"category_scores_gemma":[0.0001334996,0.0002260718,0.00006012373,0.000405863,0.00004174653,0.00003334783,0.0001783149,0.000246212,0.00006545417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005490416,"about_ca_system_score_gemma":0.0001325538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002256466,"about_ca_topic_score_gemma":0.0002656542,"domain_scores_codex":[0.9981437,0.000359198,0.0004306609,0.0004333409,0.0001761983,0.0004569572],"domain_scores_gemma":[0.9993775,0.00004942933,0.000100075,0.0002864382,0.00008607556,0.0001004789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001943989,0.0001476885,0.03185409,0.00001409288,0.00002716981,0.00007842494,0.0005663342,0.001492463,0.9616145,0.00000472085,0.00002985843,0.002226632],"study_design_scores_gemma":[0.001658121,0.000295625,0.05244134,0.00005217955,0.00002065981,0.0000112141,0.0008679844,0.008348051,0.9348518,0.00001516653,0.00113625,0.0003016502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985819,0.0004720218,0.00004500658,0.000267914,0.0002824253,0.0002362198,0.00003235554,0.0000398769,0.00004221922],"genre_scores_gemma":[0.9980683,0.000583521,0.00007361044,0.0005397822,0.0001318641,0.00002292772,0.0003166536,0.00003677003,0.0002266235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02676279,"threshold_uncertainty_score":0.9218942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04153688482909806,"score_gpt":0.3452618183323994,"score_spread":0.3037249335033013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}