{"id":"W4353086070","doi":"10.54097/hset.v36i.5706","title":"Comprehensive Overview of CAR-T Cell Therapy, Engineering Process and Future Prospects","year":2023,"lang":"en","type":"article","venue":"Highlights in Science Engineering and Technology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chimeric antigen receptor; Immune system; Antigen; Cancer research; Cell therapy; Antigen-presenting cell; Immunology; Immunotherapy; Cytotoxic T cell; T cell; Medicine; Biology; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008335094,0.0008061386,0.0008627631,0.001877097,0.000341595,0.001483494,0.0008636683,0.001379458,0.0053671],"category_scores_gemma":[0.0004506357,0.0004177602,0.0008102348,0.001684834,0.0003553878,0.002140891,0.000624778,0.001713518,0.003150593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009535044,"about_ca_system_score_gemma":0.001057578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009971561,"about_ca_topic_score_gemma":0.0009156124,"domain_scores_codex":[0.9996926,0.00004959835,0.00003255831,0.00006820144,0.0001134826,0.00004366466],"domain_scores_gemma":[0.999813,0.00006528418,0.00002132695,0.000009857527,0.00006615693,0.00002441172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001501992,0.0002460839,0.0004910808,0.009482224,0.00005307011,0.0003301132,0.0001065714,0.001582465,0.01372658,0.02145813,0.03669721,0.9156762],"study_design_scores_gemma":[0.00001485837,0.0002943749,0.0003980993,0.0007248286,0.00005835756,0.001272025,0.00004193024,0.0007410651,0.005418518,0.00376871,0.987237,0.00003018261],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001276738,0.9786327,0.006808362,0.00126299,0.0007618415,0.00007062971,0.0001195171,0.0001161014,0.01095118],"genre_scores_gemma":[0.00544817,0.9820011,0.004496638,0.0009811916,0.0006852041,0.0001043567,0.0002826665,0.0000246978,0.005976017],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0053671,"threshold_uncertainty_score":0.01795477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946092738117023,"score_gpt":0.2898205184973282,"score_spread":0.2703595911161579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}