{"id":"W4353086070","doi":"10.54097/hset.v36i.5706","title":"Comprehensive Overview of CAR-T Cell Therapy, Engineering Process and Future Prospects","year":2023,"lang":"en","type":"article","venue":"Highlights in Science Engineering and Technology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chimeric antigen receptor; Immune system; Antigen; Cancer research; Cell therapy; Antigen-presenting cell; Immunology; Immunotherapy; Cytotoxic T cell; T cell; Medicine; Biology; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000207027,0.0001464535,0.0003028137,0.00122737,0.00004578571,0.00001550892,0.0001686015,0.0001305195,0.000009292262],"category_scores_gemma":[0.00003216636,0.0001185165,0.00001761445,0.003185004,0.0002846009,0.00007919496,0.00009875164,0.0002577135,0.000004605346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003769625,"about_ca_system_score_gemma":0.00006923448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000067633,"about_ca_topic_score_gemma":8.127938e-7,"domain_scores_codex":[0.9988154,0.00000386144,0.0001730447,0.0003480399,0.0002762547,0.000383408],"domain_scores_gemma":[0.9994786,0.00004509481,0.00002859385,0.0002516316,0.000113706,0.00008240669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001947044,0.00003665936,0.002248039,0.0005686011,0.00001193469,0.0000700351,0.0005784843,0.0003031071,0.9815416,0.00893253,0.00001281124,0.005676699],"study_design_scores_gemma":[0.002470678,0.0006901257,0.04076039,0.000435391,0.00001285065,0.0002156821,0.0006677844,0.02214238,0.8719725,0.0003187261,0.05988209,0.0004314175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930728,0.004826009,0.000007468268,0.001268919,0.0001371072,0.0003273486,0.000001917471,0.0002505366,0.0001078619],"genre_scores_gemma":[0.9908545,0.008466517,0.0004510522,0.000008847948,0.00006324067,0.00003621426,0.000001036974,0.00001932376,0.00009929363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1095691,"threshold_uncertainty_score":0.4832961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946092738117023,"score_gpt":0.2898205184973282,"score_spread":0.2703595911161579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}