{"id":"W4355260","doi":"10.1023/a:1011379307472","title":"XIAP: Apoptotic brake and promising therapeutic target","year":2001,"lang":"en","type":"review","venue":"APOPTOSIS","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":384,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"XIAP; Inhibitor of apoptosis; Caspase; Cell biology; Programmed cell death; Apoptosis; Biology; Internal ribosome entry site; Signal transduction; Intrinsic apoptosis; Chemistry; Translation (biology); Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008818288,0.001606251,0.002018616,0.001714988,0.0005047435,0.001430558,0.001452275,0.002147419,0.003598648],"category_scores_gemma":[0.0006771052,0.0004208796,0.0003342531,0.00203507,0.001141581,0.002095071,0.0006215598,0.003873265,0.004183427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001120548,"about_ca_system_score_gemma":0.0007787035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005420013,"about_ca_topic_score_gemma":0.001232857,"domain_scores_codex":[0.9998193,0.00003007672,0.00002416507,0.00003805639,0.00006373658,0.00002463452],"domain_scores_gemma":[0.9996725,0.0001552756,0.00003216941,0.00001613525,0.00008204813,0.00004194407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002789097,0.00009956941,0.0001529508,0.005197289,0.00005787236,0.0005744388,0.00004659475,0.0006774872,0.005687774,0.006649581,0.08830171,0.8922758],"study_design_scores_gemma":[0.00007177208,0.000133283,0.0003322206,0.000699943,0.00008079554,0.002406318,0.00004429097,0.0001452449,0.001910683,0.003630022,0.9905247,0.0000206972],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001972905,0.9943312,0.0009444694,0.0008343682,0.001082941,0.000009532037,0.00002913689,0.00003253637,0.002538484],"genre_scores_gemma":[0.002007456,0.9892222,0.001232952,0.001129463,0.001107062,0.00004390868,0.00009922095,0.00000833488,0.005149361],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003598648,"threshold_uncertainty_score":0.01203871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02819437091031617,"score_gpt":0.2943076471253771,"score_spread":0.2661132762150609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}