{"id":"W4355260","doi":"10.1023/a:1011379307472","title":"XIAP: Apoptotic brake and promising therapeutic target","year":2001,"lang":"en","type":"review","venue":"APOPTOSIS","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":384,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"XIAP; Inhibitor of apoptosis; Caspase; Cell biology; Programmed cell death; Apoptosis; Biology; Internal ribosome entry site; Signal transduction; Intrinsic apoptosis; Chemistry; Translation (biology); Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001529026,0.0003694361,0.0006553674,0.00008153321,0.0001125751,0.00005915627,0.0001528263,0.0004939816,0.00004910514],"category_scores_gemma":[0.00001170724,0.0002959594,0.0002833596,0.0001432384,0.00005021867,0.000003111209,0.0001074867,0.0001385272,0.00001750474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001978496,"about_ca_system_score_gemma":0.00007496009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006679239,"about_ca_topic_score_gemma":0.00000107149,"domain_scores_codex":[0.9986303,0.00008742078,0.0003394588,0.0005399741,0.0001205581,0.0002823106],"domain_scores_gemma":[0.9992828,0.00001441907,0.0001919371,0.0003860519,0.00003358557,0.00009119504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003862795,0.00002711546,0.000001778865,0.001580025,0.000153591,5.381667e-7,0.000008594654,0.000001072962,0.002352437,0.0001055586,0.000124725,0.9956407],"study_design_scores_gemma":[0.000138518,0.0000955432,0.000002489231,0.001012131,0.0003869355,0.00004496653,0.000006060657,0.000009730298,0.002395409,0.0001338959,0.9954041,0.000370219],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003902095,0.9965231,0.0017799,0.0000180572,0.000212501,0.0005265561,0.00001120001,0.00001983193,0.0005186407],"genre_scores_gemma":[0.0003915945,0.9955881,0.0009491416,0.00006337721,0.0003660023,0.00005769637,0.0003365879,0.00007593988,0.002171584],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9952794,"threshold_uncertainty_score":0.9999493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02819437091031617,"score_gpt":0.2943076471253771,"score_spread":0.2661132762150609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}