{"id":"W4360593151","doi":"10.2139/ssrn.4385123","title":"Modeling the Cytotoxicity of Latency Reversal Agents Reveals the Ineffectiveness of the 'Shock and Kill' Strategy","year":2023,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University","funders":"","keywords":"Cytotoxicity; Latency (audio); Shock (circulatory); Chemistry; Pharmacology; Medicine; Computer science; Biochemistry; Internal medicine; In vitro; Telecommunications","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001360995,0.0001199172,0.0001399387,0.00002516219,0.0002420363,0.00001425295,0.0003833582,0.00009311787,0.000002255313],"category_scores_gemma":[0.00009552543,0.00006103523,0.0001285038,0.0002071039,0.0001228663,0.000004173655,0.0001165557,0.0005054628,9.870594e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003998472,"about_ca_system_score_gemma":0.0004908735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005074639,"about_ca_topic_score_gemma":0.00070208,"domain_scores_codex":[0.9985439,0.0002238217,0.0002529875,0.0001460769,0.0001941675,0.0006390802],"domain_scores_gemma":[0.9993618,0.00002897423,0.0001566412,0.0003077064,0.0001213363,0.00002355629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002656193,0.0000568078,0.01292576,0.0000635944,0.0004468627,0.000001026495,0.0004000312,0.01927096,0.9605868,0.003522776,0.0002837547,0.002176045],"study_design_scores_gemma":[0.004754093,0.002915213,0.1638949,0.0004783133,0.0007210011,0.0009622807,0.007780117,0.008990911,0.5277578,0.2783187,0.002104006,0.001322719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960217,0.002497303,0.000847225,0.0002659718,0.00007969509,0.0001845302,0.00000705444,0.000002977235,0.00009349712],"genre_scores_gemma":[0.9926922,0.006526192,0.00000805401,0.00005888677,0.0001241644,0.000005514548,0.000003864131,0.00001393405,0.0005671656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.432829,"threshold_uncertainty_score":0.2488944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336879848247818,"score_gpt":0.2620355656881186,"score_spread":0.2486667672056404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}