{"id":"W4360593151","doi":"10.2139/ssrn.4385123","title":"Modeling the Cytotoxicity of Latency Reversal Agents Reveals the Ineffectiveness of the 'Shock and Kill' Strategy","year":2023,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University","funders":"","keywords":"Cytotoxicity; Latency (audio); Shock (circulatory); Chemistry; Pharmacology; Medicine; Computer science; Biochemistry; Internal medicine; In vitro; Telecommunications","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322172,0.0003326905,0.0002823435,0.0001542204,0.0001333548,0.0003840116,0.0005607241,0.0004395399,0.003483783],"category_scores_gemma":[0.0004503568,0.0001048494,0.0002449168,0.0001073297,0.0002335548,0.0005945236,0.0001427698,0.0005407984,0.0007802128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004712727,"about_ca_system_score_gemma":0.0004809269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002985463,"about_ca_topic_score_gemma":0.002373477,"domain_scores_codex":[0.9999461,0.000005765822,0.000002918166,0.00001308954,0.00001483298,0.00001739549],"domain_scores_gemma":[0.9998941,0.00003849226,0.00002855217,0.00001091948,0.00001768675,0.00001020541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000332992,0.0002910597,0.002530935,0.0002815395,0.00004375176,0.0004172213,0.00007422605,0.5992197,0.3381556,0.034414,0.001397898,0.02284117],"study_design_scores_gemma":[0.0000243799,0.000431386,0.0008868881,0.00000920119,0.00003261558,0.0001262401,0.00004441191,0.9119167,0.08084053,0.003722461,0.001947859,0.00001727914],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9310433,0.000503357,0.04818865,0.000462997,0.00005505516,0.00004418414,0.0004427523,0.0002692413,0.01899039],"genre_scores_gemma":[0.9925928,0.0002974756,0.00342771,0.00005447726,0.000003585716,0.00002171101,0.0001026355,0.00003111632,0.003468512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003483783,"threshold_uncertainty_score":0.01165438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336879848247818,"score_gpt":0.2620355656881186,"score_spread":0.2486667672056404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}