{"id":"W4360599615","doi":"10.3324/haematol.2023.282791","title":"Molecular targeting of the UDP-glucuronosyltransferase enzymes in high-eukaryotic translation initiation factor 4E refractory/relapsed acute myeloid leukemia patients: a randomized phase II trial of vismodegib, ribavirin with or without decitabine","year":2023,"lang":"en","type":"article","venue":"Haematologica","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Jewish General Hospital","funders":"Janssen Pharmaceuticals; Genentech; Fondation de l'Hôpital général juif; Leukemia and Lymphoma Society; Jazz Pharmaceuticals; F. Hoffmann-La Roche; Gilead Sciences; Jewish General Hospital; Sanofi","keywords":"Decitabine; Cytarabine; Myeloid leukemia; Pharmacology; Medicine; Internal medicine; Deoxycytidine kinase; Oncology; Cancer research; Biology; Deoxycytidine; Chemotherapy; Gemcitabine; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008871999,0.0009034846,0.00132155,0.0002923317,0.0002383923,0.0008140928,0.0004158597,0.0007103738,0.003122706],"category_scores_gemma":[0.0005230206,0.0004197561,0.001007447,0.0002249946,0.0006385244,0.000643249,0.0002914545,0.002218023,0.0003643984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006592686,"about_ca_system_score_gemma":0.0007514721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000519862,"about_ca_topic_score_gemma":0.002171041,"domain_scores_codex":[0.9997324,0.00009987983,0.00001676009,0.00005975689,0.00002344317,0.00006761934],"domain_scores_gemma":[0.9997888,0.00003282715,0.00004551071,0.00001984908,0.00001353253,0.00009942908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7990423,0.03050081,0.002865352,0.0006646956,0.001420599,0.0001004591,0.0001478063,0.001893087,0.06743988,0.000441722,0.00166554,0.09381774],"study_design_scores_gemma":[0.6446667,0.3264808,0.009120935,0.00004887714,0.001128272,0.000212424,0.00007164522,0.001819158,0.01183614,0.0004291298,0.004141007,0.00004493798],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951116,0.002063277,0.0002714345,0.0003959996,0.000129357,0.0009262977,0.0002786662,0.00004237912,0.0007810377],"genre_scores_gemma":[0.9938353,0.00135133,0.0009115766,0.0005492215,0.0001067009,0.001147392,0.0004757243,0.00001762919,0.001605135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003122706,"threshold_uncertainty_score":0.01044655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01726773215579263,"score_gpt":0.2759986050334017,"score_spread":0.258730872877609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}