{"id":"W4360600077","doi":"10.1080/22221751.2023.2195020","title":"Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade","year":2023,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Intestinal Research; Simon Fraser University; University of British Columbia; Institute of Infection and Immunity","funders":"Center for the Management of Systemic Risk, Columbia University; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit van Amsterdam; ZonMw; Australian Prime Ministers Centre; Amsterdam University Medical Centers","keywords":"Autophagy; Viral entry; Blockade; Biology; Virus; Immunology; Virology; Viral replication; Medicine; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002078382,0.0003354325,0.0003661985,0.0006404697,0.0004621907,0.00005871045,0.000106077,0.0001481775,0.0005352629],"category_scores_gemma":[0.0001265612,0.0003354962,0.0002854283,0.001194529,0.0001188121,0.0002085041,0.0001163132,0.0004357361,0.001118556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001502113,"about_ca_system_score_gemma":0.0001243706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046491,"about_ca_topic_score_gemma":0.0002085225,"domain_scores_codex":[0.9981814,0.00007730462,0.0004455525,0.0004850863,0.0002550017,0.0005556706],"domain_scores_gemma":[0.9989823,0.0001147404,0.0001272217,0.0004687067,0.0001741356,0.0001328995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005872989,0.0007524308,0.01417064,0.0001339996,0.0004438375,0.0001569185,0.0004412054,0.0002797874,0.9671175,0.0001233919,0.0110115,0.005310006],"study_design_scores_gemma":[0.001791433,0.0004684874,0.05510096,0.0002417907,0.0004972075,0.001020657,0.00005011374,0.001385042,0.8741384,0.0006097563,0.06424821,0.0004479845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99023,0.0004109575,0.003211463,0.0007919578,0.001200452,0.0004539529,0.00002137318,0.001631738,0.002048064],"genre_scores_gemma":[0.9951758,0.0003839997,0.0002077294,0.0004584586,0.00065921,0.00014897,0.0001775342,0.00008293587,0.002705351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09297919,"threshold_uncertainty_score":0.9999097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02216658682610841,"score_gpt":0.3190618246700471,"score_spread":0.2968952378439387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}