{"id":"W4360600077","doi":"10.1080/22221751.2023.2195020","title":"Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade","year":2023,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Intestinal Research; Simon Fraser University; University of British Columbia; Institute of Infection and Immunity","funders":"Center for the Management of Systemic Risk, Columbia University; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit van Amsterdam; ZonMw; Australian Prime Ministers Centre; Amsterdam University Medical Centers","keywords":"Autophagy; Viral entry; Blockade; Biology; Virus; Immunology; Virology; Viral replication; Medicine; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007801,0.0002715238,0.0003362577,0.0001395693,0.0001137724,0.0001771872,0.0001775322,0.0002832572,0.001137036],"category_scores_gemma":[0.00006621776,0.0001036409,0.0002296599,0.00007764607,0.0001482476,0.0002018646,0.0001071999,0.0005031705,0.0002539948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997295,"about_ca_system_score_gemma":0.0002004799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004183123,"about_ca_topic_score_gemma":0.001085073,"domain_scores_codex":[0.999929,0.00001545482,0.000007287777,0.00001371652,0.00001215176,0.00002245215],"domain_scores_gemma":[0.9999712,0.000004397305,0.00000817598,0.000003217425,0.000004816445,0.000008269445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007008401,0.0001545029,0.00009140081,0.0001163134,0.000009561086,0.00004086875,0.00001048208,0.00007187521,0.9959187,0.00006433286,0.0001181417,0.002702978],"study_design_scores_gemma":[0.0001806704,0.002840333,0.004816531,0.00001896101,0.00003963236,0.0003954239,0.00003355353,0.001462527,0.9848022,0.00005144989,0.005349713,0.000008959163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918731,0.003760139,0.001432871,0.0001871856,0.00005676682,0.00005472864,0.0003421304,0.0001462319,0.002146944],"genre_scores_gemma":[0.9944264,0.001571361,0.001381697,0.0001015689,0.00001470956,0.00004527088,0.0003702447,0.00001351237,0.002075295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137036,"threshold_uncertainty_score":0.00380379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02216658682610841,"score_gpt":0.3190618246700471,"score_spread":0.2968952378439387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}