{"id":"W4360601016","doi":"10.1007/s40259-023-00589-3","title":"Impact of Introducing Infliximab Biosimilars on Total Infliximab Consumption and Originator Infliximab Prices in Eight Regions: An Interrupted Time-Series Analysis","year":2023,"lang":"en","type":"article","venue":"BioDrugs","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health and Medical Research Fund; Medical Research Council; University of Hong Kong; National Institute for Health and Care Research; Australian Government; National Health and Medical Research Council; European Commission; Amgen; Pfizer; Bristol-Myers Squibb","keywords":"Biosimilar; Infliximab; Medicine; Interrupted time series; Interrupted Time Series Analysis; Consumption (sociology); Demography; Internal medicine; Tumor necrosis factor alpha","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003124425,0.0002679264,0.000557267,0.0007503697,0.0001446069,0.0009176129,0.000535585,0.0004478616,0.001066874],"category_scores_gemma":[0.007930735,0.0002024261,0.001606846,0.001733316,0.0003005699,0.0004078747,0.0004850742,0.000784192,0.0001770623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008372806,"about_ca_system_score_gemma":0.0007121846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02510648,"about_ca_topic_score_gemma":0.01142612,"domain_scores_codex":[0.99762,0.001103675,0.0002252235,0.0004710699,0.0003386799,0.00024122],"domain_scores_gemma":[0.9918672,0.002762317,0.003677534,0.0004878636,0.0008514356,0.0003536535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001804289,0.0001487215,0.9853976,0.00009704108,0.001295833,0.0002441025,0.0004025259,0.003553875,0.0008934648,0.0001568113,0.0002875194,0.005718084],"study_design_scores_gemma":[0.00002693265,0.0003524259,0.9887228,0.00001755601,0.0004355835,0.0001000949,0.0002943272,0.009161774,0.0003611752,0.00004537508,0.0004659875,0.00001599285],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977351,0.0003154996,0.0006400492,0.0000589291,0.00001037048,0.00001244901,0.000939257,0.000008410103,0.0002799704],"genre_scores_gemma":[0.9976225,0.0001572159,0.000435632,0.00002936119,0.000007599088,0.00002295737,0.00140956,0.000005161763,0.0003100774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02510648,"threshold_uncertainty_score":0.04992068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02306556960911271,"score_gpt":0.3292944411009679,"score_spread":0.3062288714918552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}