{"id":"W4360601016","doi":"10.1007/s40259-023-00589-3","title":"Impact of Introducing Infliximab Biosimilars on Total Infliximab Consumption and Originator Infliximab Prices in Eight Regions: An Interrupted Time-Series Analysis","year":2023,"lang":"en","type":"article","venue":"BioDrugs","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health and Medical Research Fund; Medical Research Council; University of Hong Kong; National Institute for Health and Care Research; Australian Government; National Health and Medical Research Council; European Commission; Amgen; Pfizer; Bristol-Myers Squibb","keywords":"Biosimilar; Infliximab; Medicine; Interrupted time series; Interrupted Time Series Analysis; Consumption (sociology); Demography; Internal medicine; Tumor necrosis factor alpha","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007631847,0.0003661293,0.0008152126,0.001379391,0.0001202531,0.00004930906,0.0002478213,0.0004454672,0.000497718],"category_scores_gemma":[0.0003135783,0.0002836912,0.0002738012,0.001875503,0.0005981078,0.0003276537,0.00016757,0.0003727716,0.0001095078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001225996,"about_ca_system_score_gemma":0.00007527038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000151832,"about_ca_topic_score_gemma":0.00004966936,"domain_scores_codex":[0.997708,0.0003242657,0.0006715362,0.0006737819,0.00009907549,0.0005233319],"domain_scores_gemma":[0.9986686,0.0003188788,0.0002805582,0.0005397827,0.0001142353,0.00007797431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005880137,0.001864076,0.4115508,0.000278254,0.006957017,0.00006377898,0.005128696,0.0002729707,0.5338472,0.003214245,0.0076407,0.02330216],"study_design_scores_gemma":[0.005162547,0.002818449,0.8990749,0.0002533766,0.001076536,0.00006067242,0.000616569,0.001678815,0.08223318,0.0005326861,0.005372234,0.001120053],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974874,0.000816495,0.00004020768,0.0006941662,0.0001785104,0.0003072545,0.0001937868,0.0001269895,0.0001551366],"genre_scores_gemma":[0.9975277,0.0004848232,0.001018432,0.0001407549,0.00003952406,0.00002688804,0.0002600632,0.00002602621,0.0004757694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4875242,"threshold_uncertainty_score":0.9999615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02306556960911271,"score_gpt":0.3292944411009679,"score_spread":0.3062288714918552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}